A Novel Wound Dressing Nanofiber with Anti-inflammatory and Anti-bacterial Drugs Release for Skin Wound Healing

Document Type : Original Article (s)

Authors

1 MSc Student, Student Research Committee, Department of Biomedical Engineering, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Department of Biomaterials Nanotechnology and Tissue Engineering, School of Advanced Medical Technology, Isfahan University of Medical Sciences, Isfahan, Iran

3 Professor, Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: The skin is always damaged by burns, physical damages, and diseases such as diabetes mellitus. Infection and acute inflammation of wounds caused by burns and diabetes ulcers lead to extensive damage and death. Therefore, it is necessary the design polymeric dressings containing drugs with controlling ability to release the drugs in wound site.Methods: Wound dressing of poly(glycerol sebacate) (PGS)/ polyhydroxybutyrate (PHB) was fabricated by coaxial electrospinning process. These fibers were characterized by scanning electron microscope (SEM) images. The anti-bacterial activity, cell viability (MTT) and cell adhesion were investigated.Findings: The results of SEM showed that the wound fibers were uniform, and with a diameter of 575 ± 40.6 nm. The drugs loaded were separately in the core and shell of fibers. The samples containing drugs showed good bactericidal activity against both of Gram-positive and Gram-negative bacteria. Result of MTT did not show viability, attachment, and growth of cells in wound dressing with drugs.Conclusion: It can be concluded that this wound dressing with the release of two drugs simultaneously is an ideal wound dressing to control the infection, and heal the wound.

Keywords

References

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Journal of Isfahan Medical School
Volume 36, Issue 505 - Serial Number 505
November and December 2019
Pages 1428-1433

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History

  • Receive Date: 27 June 2018
  • Revise Date: 09 November 2024
  • Accept Date: 06 April 2022

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