Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effects of Estrogen on Passive Avoidance Memory Impairment Induced by Acute Kidney Injury in Ovariectomized Rats

Document Type : Original Article (s)

Authors
Fatemeh Sharifi 1
Parham Reisi 2
Maryam Malek 3
1 MSc Student, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Assistant Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v37i515.11140
Abstract
Background: The aim of this study was to evaluate the effects of acute kidney injury (AKI) and mediatory role of the estrogen on passive avoidance memory in ovariectomized rats.Methods: Frothy ovariectomized Wistar rats were subjected to sham-vehicle, sham-estrogen, renal ischemia reperfusion (RIR)-vehicle, and RIR-estrogen groups. AKI was induced by ischemia reperfusion. Estrogen (200 μg/kg in 0.2 ml/100 g body weight) was injected subcutaneously once a week for four weeks. Then, passive avoidance memory was assessed.Findings: AKI resulted a significant decrease in the mean latency of entering the dark chamber (P < 0.010). Although, estrogen therapy following AKI led to elevated blood urea nitrogen (BUN) and creatinine, but, there was no significant difference in the delay in entering the dark chamber in RIR-estrogen group compared to RIR-vehicle group (P = 0.100).Conclusion: The results showed that AKI could have a deleterious effect on passive avoidance memory. However, the studied dose of estrogen cannot prevent passive avoidance memory impairment induced by AKI.
Keywords
Acute Kidney Injury
Ovariectomy
Memory
Estrogen
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Journal of Isfahan Medical School
Volume 37, Issue 515 - Serial Number 515
January and February 2019
Pages 86-92

  • Receive Date 12 December 2018
  • Accept Date 06 April 2022