Comparison of Maternal Blood Lead Level in Term and Preterm Births in Pregnant Women in Alzahra Hospital, Isfahan, Iran, in Year 2018

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine AND Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine AND Child Growth and Development Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

3 Student of Medicine, Student Research Committee AND Department of Obstetrics and Gynecology, School of Medicine AND Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Attentions have recently been paid to the effects of contact with lead (Pb) and blood lead levels (BLL) on prenatal complications. Given the high prevalence of preterm labor and its following neonatal complications, this study aimed to evaluate the BLL in pregnant mothers and its relation with preterm labor.Methods: Throughout a cross-sectional analytical descriptive study, 63 women with preterm labor and 63 cases with term labor participated. A blood sample was obtained from each mother by the same nurse and BLLs were compared between the two groups. Other collected data included mother’s age and sex, and neonates’ head circumference, height, and weight.Findings: Newborns in term and preterm groups weighed 2009.80 ± 70.1 and 3239.44 ± 35.80 grams respectively; their mean height was 50.46 ± 0.10 and 44.00 ± 0.40 cm, and their mean head circumference was 34.47 ± 0.1 and 31.49 ± 0.30 cm, respectively. The mean BLL of mothers in term and preterm newborns was 2.05 ± 0.10 and 3.01 ± 0.1 μg/dl, respectively (P = 0.04).Conclusion: BLL in mothers with preterm labor was significantly higher than in mothers with preterm labor.

Keywords


  1. Arroyo V, Diaz J, Ortiz C, Carmona R, Saez M, Linares C. Short term effect of air pollution, noise and heat waves on preterm births in Madrid (Spain). Environ Res 2016; 145: 162-8.
  2. Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Requejo JH, et al. The worldwide incidence of preterm birth: A systematic review of maternal mortality and morbidity. Bull World Health Organ 2010; 88(1): 31-8.
  3. Alijahan R, Hazrati S, Mirzarahimi M, Pourfarzi F, Ahmadi HP. Prevalence and risk factors associated with preterm birth in Ardabil, Iran. Iran J Reprod Med 2014; 12(1): 47-56.
  4. Golestan M, Akhavan KS, Fallah R. Prevalence and risk factors for low birth weight in Yazd, Iran. Singapore Med J 2011; 52(10): 730-3.
  5. Lotf Alizadeh M, Mohammadzadeh A, Kamandi S, Bagheri S. Prevalanace and risk factors of preterm labor in Imam Reza Hospital (1381-1382). Iran J Obstet Gynecol Infertil 2005; 8(2): 93-100. [In Persian].
  6. Amini L, Mahmoudi Z, Hosseini F, Mahmoudi A. The relationship between the social structure and health and pregnancy outcomes: Preterm labor and rupture of water bag. J Sabzevar Univ Med Sci 2013; 20(1): 109-15. [In Persian].
  7. do Carmo Leal M, Esteves-Pereira AP, Nakamura-Pereira M, Torres JA, Theme-Filha M, Domingues RM, et al. Prevalence and risk factors related to preterm birth in Brazil. Reprod Health 2016; 13(Suppl 3): 127.
  8. Perkins M, Wright RO, Amarasiriwardena CJ, Jayawardene I, Rifas-Shiman SL, Oken E. Very low maternal lead level in pregnancy and birth outcomes in an eastern Massachusetts population. Ann Epidemiol 2014; 24(12): 915-9.
  9. Gulson BL, Mizon KJ, Korsch MJ, Palmer JM, Donnelly JB. Mobilization of lead from human bone tissue during pregnancy and lactation--a summary of long-term research. Sci Total Environ 2003; 303(1-2): 79-104.
  10. Bayat F, Akbari SA, Dabirioskoei A, Nasiri M, Mellati A. The relationship between blood lead level and preeclampsia. Electron Physician 2016; 8(12): 3450-5.
  11. Manton WI, Angle CR, Stanek KL, Kuntzelman D, Reese YR, Kuehnemann TJ. Release of lead from bone in pregnancy and lactation. Environ Res 2003; 92(2): 139-51.
  12. Taylor CM, Golding J, Emond AM. Adverse effects of maternal lead levels on birth outcomes in the ALSPAC study: A prospective birth cohort study. BJOG 2015; 122(3): 322-8.
  13. Jedrychowski WA, Perera FP, Majewska R, Mrozek-Budzyn D, Mroz E, Roen EL, et al. Depressed height gain of children associated with intrauterine exposure to polycyclic aromatic hydrocarbons (PAH) and heavy metals: The cohort prospective study. Environ Res 2015; 136: 141-7.
  14. Vigeh M, Yokoyama K, Seyedaghamiri Z, Shinohara A, Matsukawa T, Chiba M, et al. Blood lead at currently acceptable levels may cause preterm labour. Occup Environ Med 2011; 68(3): 231-4.
  15. Afkhami B, Lamyian M, Hajizadeh E. The Association between maternal blood lead levels and preterm birth. J Mazandaran Univ Med Sci 2012; 2(90): 19-24. [In Persian].
  16. Rabito FA, Kocak M, Werthmann DW, Tylavsky FA, Palmer CD, Parsons PJ. Changes in low levels of lead over the course of pregnancy and the association with birth outcomes. Reprod Toxicol 2014; 50: 138-44.