The Relationship between Consanguineous Marriage and Hearing Loss in Patients Referring to Isfahan Cochlear Implant Center, Iran

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Otorhinolaryngology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Instructor, Musculoskeletal Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: The distinction of sensorineural hearing loss (SNHL) causes is important for the prevention and treatment. In this study, we aimed to investigate the relationship between consanguineous marriage and hearing loss resulting cochlear implant.Methods: In this descriptive cross-sectional study from April 2017 to April 2018, 680 patients with severe to profound SNHL referring to Isfahan Cochlear Implantation Center, Isfahan, Iran, were investigated. A checklist was designed to collect available patients' records information including demographic characteristics of the cases and the consanguineous marriage of their parents. Statistical analysis was performed using SPSS software.Findings: In patients resulting from consanguineous marriage, 184 cases (44.1%) had profound hearing loss, 116 (27.8%) severe to profound hearing loss, 40 (9.6%) severe hearing loss, 68 (16.3%) moderate to severe hearing loss, and 9 (2.2%) moderate hearing loss; these values for patients of non-consanguineous marriage were 108 (41.1%), 100 (38.1%), 19 (7.2%), 33 (12.5%), and 3 (1.1%) cases, respectively (P = 0.13). Furthermore, there was no significant difference between the types of consanguineous marriage in terms of severity of hearing loss (P = 0.61).Conclusion: In according to results, consanguineous marriage has high prevalence among children with SNHL, but there is no significant association between the types of consanguineous marriage with severity of hearing loss in children with SNHL resulting in cochlear implantation.

Keywords

References

  1. Kayyali MN, Wright AC, Ramsey AJ, Brant JA, Stein JM, O'Malley BW, et al. Challenges and opportunities in developing targeted molecular imaging to determine inner ear defects of sensorineural hearing loss. Nanomedicine 2018; 14(2): 397-404.
  2. Ghasemnejad T, Shekari KM, Zarei F, Farbodnia M, Mansoori DS. An update of common autosomal recessive non-syndromic hearing loss genes in Iranian population. Int J Pediatr Otorhinolaryngol 2017; 97: 113-26.
  3. Chetcuti K, Kumbla S. The internal acoustic canal--another review area in paediatric sensorineural hearing loss. Pediatr Radiol 2016; 46(4): 562-9.
  4. Subasioglu A, Duman D, Sirmaci A, Bademci G, Carkit F, Somdas MA, et al. Research of genetic bases of hereditary non-syndromic hearing loss. Turk Pediatri Ars 2017; 52(3): 122-32.
  5. Hussain S, Khattak JZ, Ismail M, Mansoor Q, Khan MH. Molecular characterization of autosomal recessive non syndromic hearing loss in selected families from District Mardan, Pakistan. Pak J Pharm Sci 2018; 31(1): 51-6.
  6. Stelma F, Bhutta MF. Non-syndromic hereditary sensorineural hearing loss: Review of the genes involved. J Laryngol Otol 2014; 128(1): 13-21.
  7. Xia W, Liu F, Ma D. Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness. Front Med 2016; 10(2): 137-42.
  8. Xia W, Hu J, Liu F, Ma J, Sun S, Zhang J, et al. New role of LRP5, associated with nonsyndromic autosomal-recessive hereditary hearing loss. Hum Mutat 2017; 38(10): 1421-31.
  9. Oonk AM, Huygen PL, Kunst HP, Kremer H, Pennings RJ. Features of autosomal recessive non-syndromic hearing impairment: A review to serve as a reference. Clin Otolaryngol 2016; 41(5): 487-97.
  10. Fareed M, Afzal M. Genetics of consanguinity and inbreeding in health and disease. Ann Hum Biol 2017; 44(2): 99-107.
  11. Small N, Bittles AH, Petherick ES, Wright J. Endogamy, consanguinity and the health implications of changing marital choices in the UK Pakistani Community. J Biosoc Sci 2017; 49(4): 435-46.
  12. Saadat M, Zarghami M. Consanguineous marriages among Iranian Mandaeans living in south-west Iran. J Biosoc Sci 2018; 50(4): 451-6.
  13. Beheshtian M, Babanejad M, Azaiez H, Bazazzadegan N, Kolbe D, Sloan-Heggen C, et al. Heterogeneity of hereditary hearing loss in Iran: A comprehensive review. Arch Iran Med 2016; 19(10): 720-8.
  14. Sanyelbhaa H, Kabel A, Abo El-Naga HAE, Sanyelbhaa A, Salem H. The risk ratio for development of hereditary sensorineural hearing loss in consanguineous marriage offspring. Int J Pediatr Otorhinolaryngol 2017; 101: 7-10.
  15. Bener A, Eihakeem AA, Abdulhadi K. Is there any association between consanguinity and hearing loss. Int J Pediatr Otorhinolaryngol 2005; 69(3): 327-33.
  16. Zakzouk S. Consanguinity and hearing impairment in developing countries: A custom to be discouraged. J Laryngol Otol 2002; 116(10): 811-6.
  17. Kavitha Y, Sabarigirish K, Joish UK, Saxena S, Dutta A. A study of effect of consanguinity on cochlear morphology in patients with congenital bilateral profound sensorineural hearing loss. Indian J Otolaryngol Head Neck Surg 2017; 69(4): 483-7.
Journal of Isfahan Medical School
Volume 37, Issue 529 - Serial Number 529
May and June 2019
Pages 587-592

Files

History

  • Receive Date: 11 June 2018
  • Revise Date: 05 May 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics