The Therapeutic Effect of Acoustic Cavitation on Breast Carcinoma Tumor Model in BALB/c Mice in the Presence of Gold Nanoparticles

Document Type : Original Article (s)

Authors

1 PhD Student, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Professor, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Acoustic cavitation, which occurs at high intensities of ultrasound waves, can be fatal for tumor cells. On the other hand, the existence of nanoparticles in a liquid decreases the acoustic cavitation onset threshold. In this study, the combined effects of ultrasound and gold nanoparticles on breast carcinoma tumor model in BALB/c mice were studied.Methods: The tumor-bearing mice were divided into 4 groups of control, gold nanoparticles, ultrasound, and ultrasound in the presence of gold nanoparticles. Therapeutic effects on tumors were evaluated by measuring relative tumor volume, doubling time, and 5-folding time for tumor volume.Findings: The 5-folding time showed a significant difference between ultrasound in the presence of the gold nanoparticles and the other groups. The maximum doubling and 5-folding times were found in the ultrasound in the presence of gold nanoparticles group.Conclusion: Combined effects of ultrasound and gold nanoparticles can be used as a method for increasing the efficiency of the treatment of carcinoma tumors.

Keywords

References

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Journal of Isfahan Medical School
Volume 37, Issue 531 - Serial Number 531
May and June 2019
Pages 667-672

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History

  • Receive Date: 23 June 2019
  • Revise Date: 04 May 2024
  • Accept Date: 06 April 2022

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