Journal of Isfahan Medical School

Journal of Isfahan Medical School

Antispasmodic Effect of Hydroalcoholic Extracts of Rosemary and Lavender on Rat Isolated Uterus Contractions

Document Type : Original Article (s)

Authors
Hassan Sadraei 1
Gholamreza Asghari 2
Nafiseh Vasileha 3
1 Associate Professor, Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2 Professor, Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
3 Student of Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v37i546.12312
Abstract
Background: In traditional medicine, Lavender and Rosemary are referred as antispasmodic agents. However, so far their direct effects on uterus contraction have not been reported. This study aimed to assess antispasmodic effect of hydroalcoholic extracts of rosemary and lavender on rat isolated uterus contractions.Methods: In this research, the relaxant effect of hydroalcoholic extracts of these plants on rat isolated uterus contraction induced by KCl, acetylcholine, oxytocin, and electrical field stimulation (EFS) was determined and compared with nifedipine.Findings: Hydroalcoholic extracts of Lavender and Rosemary inhibited uterus contractions induced by KCl, acetylcholine, oxytocin, and EFS in a concentration-dependent manner.Conclusion: Hydroalcoholic extracts of Lavender and Rosemary have relaxant effects on uterus smooth muscle, and can be useful in prevention of premature labor.
Keywords
Lavender
Rosemary plant
Smooth muscle
Uterus
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Journal of Isfahan Medical School
Volume 37, Issue 546 - Serial Number 546
September and October 2020
Pages 1136-1142

  • Receive Date 24 September 2019
  • Accept Date 06 April 2022