Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of Thiamine in Reducing the Symptoms of Bortezomib-Induced Peripheral Neuropathy in Patients with Multiple Myeloma

Document Type : Original Article (s)

Authors
Valiollah Mehrzad 1
Ghazal Rafiaei 2
1 Assistant Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Resident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v37i355.12320
Abstract
Background: Peripheral neuropathy is one of the most frequent side effects of bortezomib-based chemotherapy, which has the most important role in treatment of multiple myeloma. Various supplements including vitamin B group complex have been examined to prevent and treat bortezomib-induced peripheral neuropathy (BIPN), but there is no definite recommendation yet. We aimed to evaluate the role of vitamin B1 (thiamine) in prevention of BIPN in patients with multiple myeloma.Methods: This was a randomized controlled clinical trial study. Patients with multiple myeloma who were supposed to receive 4 months of bortezomib-based chemotherapy were enrolled the study and divided into two groups. The intervention group received thiamine at a dose of 300 mg per day from the beginning of treatment schedules, and the control group were observed during treatment. For assessment, we used symptoms experience questionnaire that was completed after 4 months.Findings: 29 patients were enrolled in vitamin B1 group and 29 others in control group. Peripheral neuropathy score significantly decreased after intervention with vitamin B1 in comparison with control group (P < 0.0001).Conclusion: The findings demonstrate that vitamin B1 has a significant effect on preventing and reducing the severity of peripheral neuropathy in BIPN.
Keywords
Bortezomib
Vitamin B1
Neuropathy
Multiple myeloma
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Journal of Isfahan Medical School
Volume 37, Issue 555 - Serial Number 555
November and December 2020
Pages 1347-1353

  • Receive Date 25 September 2019
  • Accept Date 06 April 2022