Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of Subcutaneous Injection of Metoclopramide, Pethidine, and Ketamine on Postoperative Pain after Inguinal Hernia Repair under General Anesthesia

Document Type : Original Article (s)

Authors
Darioush Moradi-Farsani 1
Zahra Azamian-Jazi 2
Seyed Morteza Heydari 3
Behzad Nazemroaya 1
1 Assistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Resident, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v38i572.10288
Abstract
Background: The aim of this study was to investigate the effect of subcutaneous injection of metoclopramide, pethidine, and ketamine on postoperative pain after inguinal hernia repair under general anesthesia compared to control group.Methods: In this clinical trial study, 104 patients were selected and randomly divided into four groups of 26 patients. The patients received subcutaneous injection of each drug at the incision site. In the first group, 0.5 mg/kg ketamine, in the second group, 0.75 mg/kg pethidine, in the third group, 0.1 mg/kg metoclopramide, and in the control group, normal saline were administered. We evaluated the pain intensity [by visual analog scale (VAS)], hemodynamic parameters, extubation and recovery time, drug complications, total rescue analgesic consumption, time to first analgesic request, and satisfaction score for the initial 24 hours after entrance to recovery.Findings: The mean of VAS at the most of measuring times (P < 0.050) and the mean of total rescue analgesic consumption (P = 0.007) were significantly lower in the ketamine and pethidine groups compared to metoclopramide and control groups. The satisfaction score for postoperative analgesia in pethidine group was significantly higher than the other groups (P < 0.001).Conclusion: Pethidine and ketamine have equal effects on postoperative pain; but the patients were more satisfied with pethidine. The effect of metoclopramide on the postoperative pain was lower than the other two drugs; moreover, its effect was equal to the placebo and was associated with more adverse reactions.
Keywords
Metoclopramide
Ketamine
Inguinal hernia
Postoperative pain
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Journal of Isfahan Medical School
Volume 38, Issue 572 - Serial Number 572
March and April 2020
Pages 252-259

  • Receive Date 13 June 2018
  • Accept Date 06 April 2022