Journal of Isfahan Medical School

Journal of Isfahan Medical School

Evaluation of Risk of Secondary Thyroid Cancer Caused by Neutron Dose Equivalent from Brain Tumor 3D-Conformal Radiation Therapy (3D-CRT)

Document Type : Original Article (s)

Authors
Sohail Elmtalab 1
Iraj Abedi 2
Mohammadhosein Choopan Dastjerdi 3
Ahmad Shanei 4
1 MSc Student, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Assistant Professor, Reactor and Nuclear Safety Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Isfahan, Iran
4 Associate Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v38i586.13087
Abstract
Background: Thyroid cancer is one of the most common secondary malignancies as a result of receiving therapeutic doses to the head and neck. In this study, the probability of secondary thyroid cancer risk due to neutron contamination of 15 MV Siemens Linear Accelerator (LINAC) in brain tumor 3D-Conformal Radiation Therapy (3D-CRT) was calculated.Methods: Neutron fluence and neutron dose were measured at different points at the treatment table using an energy-independent neutron detector consisting of a sphere moderator and a Boron Trifluoride (BF3) counter, and the neutron dose equivalent to the thyroid was determined to calculate the probability of secondary cancer risk.Findings: The neutron dose equivalent was obtained at the central axis (0.304 mSv/Gy) and at 4 cm (0.285 mSv/Gy), 15 cm (0.229 mSv/Gy), 45 cm (0.125 mSv/Gy), and 150 cm (0.02 mSv/Gy) inferior. The neutron dose equivalent reaching the thyroid for the total prescribed dose was 12.366 mSv. According to that, the probability of secondary thyroid cancer risk was obtained as 0.001%.Conclusion: The thyroid dose in high-energy radiation therapy of brain tumor cannot cause significant biological damage. Therefore, the risk of secondary thyroid cancer due to neutron contamination is relatively low.
Keywords
Radiation Dosage
Neutrons
Thyroid
Brain tumors
Radiation therapy
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Journal of Isfahan Medical School
Volume 38, Issue 586 - Serial Number 586
July and August 2020
Pages 569-574

  • Receive Date 19 May 2020
  • Accept Date 06 April 2022