Serum Vitamin D Levels in Patients with Chronic Urticaria and its Comparison with Healthy Individuals in Isfahan City, Iran

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Pediatrics, School of Medicine AND Child Growth and Development Research Center, Research Institute of Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Student Research Committee, School of medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Urticaria is an inflammatory skin disorder lasting for six weeks or longer. Nowadays, the role of vitamin D in inflammatory disease such as urticaria is a matter of great interest. The aim of this study was to investigate the relationship between vitamin D and chronic urticaria.Methods: In this cross-sectional study, 40 patients with chronic urticaria and 40 healthy individuals aged 18 to 60 years were studied during the years 2017-2018 in Alzahra hospital, Isfahan, Iran. In all cases, vitamin D levels were measured using high-performance liquid chromatography (HPLC) method. Levels of 25-hydroxyvitamin D less than 20 ng/ml were considered as deficiency and levels of 20-30 ng/ml were considered as insufficiency. Data were analyzed with appropriate statistical tests.Findings: The mean serum vitamin D level was 21.6 ng/ml in the patients group and 30.8 ng/ml in the control group. In the patient group 42.5%, and in the control group 22.5%, had vitamin D level of less than 20 ng/ml, and in the patient group 42.5%, and in the control group 25%, had vitamin D level of between 20-30 ng/ml. Therefore, the prevalence of vitamin D deficiency and insufficiency in patients and in the control group was 85% and 47.5%, respectively.Conclusion: This study shows that vitamin D deficiency is more common in people with chronic urticaria than in normal population. However, finding a cause-and-effect relationship between chronic urticaria and vitamin D requires more extensive studies.

Keywords

References

  1. Woo YR, Jung KE, Koo DW, Lee JS. Vitamin D as a marker for disease severity in chronic urticaria and its possible role in pathogenesis. Ann Dermatol 2015; 27(4): 423-30.
  2. Yuan I, Katari P, Shaker M. Vitamin D treatment for chronic urticaria: A case report. J Med Case Rep 2019; 13(1): 193.
  3. Lee SJ, Ha EK, Jee HM, Lee KS, Lee SW, Kim MA, et al. Prevalence and risk factors of urticaria with a focus on chronic urticaria in children. Allergy Asthma Immunol Res 2017; 9(3): 212-9.
  4. Maurer M, Church MK, Weller K. Chronic urticaria in children: Still itching for insight. JAMA Dermatol 2017; 153(12): 1221-2.
  5. Schoepke N, Doumoulakis G, Maurer M. Diagnosis of urticaria. Indian J Dermatol 2013; 58(3): 211-8.
  6. Asero R, Tedeschi A, Marzano AV, Cugno M. Chronic spontaneous urticaria: Immune system, blood coagulation, and more. Expert Rev Clin Immunol 2016; 12(3): 229-31.
  7. Rorie A, Poole JA. Vitamin D supplementation: A potential booster for urticaria therapy. Expert Rev Clin Immunol 2014; 10(10): 1269-71.
  8. Akbar NA, Zacharek MA. Vitamin D: Immunomodulation of asthma, allergic rhinitis, and chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 2011; 19(3): 224-8.
  9. Osborne NJ, Ukoumunne OC, Wake M, Allen KJ. Prevalence of eczema and food allergy is associated with latitude in Australia. J Allergy Clin Immunol 2012; 129(3): 865-7.
  10. Grzanka A, Machura E, Mazur B, Misiolek M, Jochem J, Kasperski J, et al. Relationship between vitamin D status and the inflammatory state in patients with chronic spontaneous urticaria. J Inflamm (Lond) 2014; 11(1): 2.
  11. Sachdeva S, Gupta V, Amin SS, Tahseen M. Chronic urticaria. Indian J Dermatol 2011; 56(6): 622-8.
  12. Rather S, Keen A, Sajad P. Serum levels of 25-hydroxyvitamin D in chronic urticaria and its association with disease activity: A case control study. Indian Dermatol Online J 2018; 9(3): 170-4.
  13. Mudavath SR, Aruna C, Ramamurthy DVSB, Sridevi K, Senthil AL, Kameti S. Evaluation of serum 25 hydroxy vitamin D levels in patients with chronic spontaneous urticaria: A hospital based cross sectional study in a tertiary care centre. J Pakistan Assoc Dermatologists 2019; 29(3): 289-93.
  14. Mohamed AA, Hussein MS, Salah EM, Eldemery A, Darwish MM, Ghaith DM, et al. Efficacy and safety of active vitamin D supplementation in chronic spontaneous urticaria patients. J Dermatolog Treat 2020; 1-6.
  15. Movahedi M, Tavakol M, Hirbod-Mobarakeh A, Gharagozlou M, Aghamohammadi A, Tavakol Z, et al. Vitamin D deficiency in chronic idiopathic urticaria. Iran J Allergy Asthma Immunol 14(2): 222-7.
  16. Quirk SK, Rainwater E, Shure AK, Agrawal DK. Vitamin D in atopic dermatitis, chronic urticaria and allergic contact dermatitis. Expert Rev Clin Immunol 2016; 12(8): 839-47.
  17. Losol P, Yoo HS, Park HS. Molecular genetic mechanisms of chronic urticaria. Allergy Asthma Immunol Res 2014; 6(1): 13-21.
  18. Bikle DD. Vitamin D and immune function: Understanding common pathways. Curr Osteoporos Rep 2009; 7(2): 58-63.
  19. Vassallo MF, Camargo CA. Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children. J Allergy Clin Immunol 2010; 126(2): 217-22.
  20. Thorp WA, Goldner W, Meza J, Poole JA. Reduced vitamin D levels in adult subjects with chronic urticaria. J Allergy Clin Immunol 2010; 126(2): 413-4.
  21. Goetz DW. Idiopathic itch, rash, and urticaria/angioedema merit serum vitamin D evaluation: a descriptive case series. W V Med J 2011; 107(1): 14-20.
  22. Sindher SB, Jariwala S, Gilbert J, Rosenstreich D. Resolution of chronic urticaria coincident with vitamin D supplementation. Ann Allergy Asthma Immunol 2012; 109(5): 359-60.
  23. Rorie A, Goldner WS, Lyden E, Poole JA. Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study. Ann Allergy Asthma Immunol 2014; 112(4): 376-82.
  24. Chandrashekar L, Rajappa M, Munisamy M, Ananthanarayanan PH, Thappa DM, Arumugam B. 25-Hydroxy vitamin D levels in chronic urticaria and its correlation with disease severity from a tertiary care centre in South India. Clin Chem Lab Med 2014; 52(6): e115-e118.
  25. Mony A, Chandrashekar L, Rajappa M, Munisamy M, Sahoo JP, Selvarajan S. Effect of vitamin D supplementation on clinical outcome and biochemical profile in South Indian population with vitamin D-deficient chronic urticarial - A randomized double-blind placebo controlled trial. Clin Chim Acta 2020; 504: 1-6.
  26. Boonpiyathad T, Pradubpongsa P, Sangasapaviriya A. Vitamin d supplements improve urticaria symptoms and quality of life in chronic spontaneous urticaria patients: a prospective case-control study. Dermatoendocrinol 2014; 6: e29727.
  27. Rasool R, Masoodi KZ, Shera IA, Yosuf Q, Bhat IA, Qasim I, et al. Chronic urticaria merits serum vitamin D evaluation and supplementation; a randomized case control study. World Allergy Organ J 2015; 8(1): 15.
  28. Tuchinda P, Kulthanan K, Chularojanamontri L, Arunkajohnsak S, Sriussadaporn S. Relationship between vitamin D and chronic spontaneous urticaria: A systematic review. Clin Transl Allergy 2018; 8: 51.
  29. Wu CH, Eren E, Ardern-Jones MR, Venter C. Association between micronutrient levels and chronic spontaneous urticaria. Biomed Res Int 2015; 2015: 926167.
Journal of Isfahan Medical School
Volume 38, Issue 591 - Serial Number 591
July and August 2020
Pages 680-685

Files

History

  • Receive Date: 05 July 2020
  • Revise Date: 06 May 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics