Journal of Isfahan Medical School

Journal of Isfahan Medical School

Serum Vitamin D Levels in Patients with Chronic Urticaria and its Comparison with Healthy Individuals in Isfahan City, Iran

Document Type : Original Article (s)

Authors
Niloufar Amini 1
Sahar Hosseini 2
1 Assistant Professor, Department of Pediatrics, School of Medicine AND Child Growth and Development Research Center, Research Institute of Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
2 Student of Medicine, Student Research Committee, School of medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v38i591.13189
Abstract
Background: Urticaria is an inflammatory skin disorder lasting for six weeks or longer. Nowadays, the role of vitamin D in inflammatory disease such as urticaria is a matter of great interest. The aim of this study was to investigate the relationship between vitamin D and chronic urticaria.Methods: In this cross-sectional study, 40 patients with chronic urticaria and 40 healthy individuals aged 18 to 60 years were studied during the years 2017-2018 in Alzahra hospital, Isfahan, Iran. In all cases, vitamin D levels were measured using high-performance liquid chromatography (HPLC) method. Levels of 25-hydroxyvitamin D less than 20 ng/ml were considered as deficiency and levels of 20-30 ng/ml were considered as insufficiency. Data were analyzed with appropriate statistical tests.Findings: The mean serum vitamin D level was 21.6 ng/ml in the patients group and 30.8 ng/ml in the control group. In the patient group 42.5%, and in the control group 22.5%, had vitamin D level of less than 20 ng/ml, and in the patient group 42.5%, and in the control group 25%, had vitamin D level of between 20-30 ng/ml. Therefore, the prevalence of vitamin D deficiency and insufficiency in patients and in the control group was 85% and 47.5%, respectively.Conclusion: This study shows that vitamin D deficiency is more common in people with chronic urticaria than in normal population. However, finding a cause-and-effect relationship between chronic urticaria and vitamin D requires more extensive studies.
Keywords
Vitamin D
Chronic urticaria
Deficiency
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Journal of Isfahan Medical School
Volume 38, Issue 591 - Serial Number 591
July and August 2020
Pages 680-685

  • Receive Date 05 July 2020
  • Accept Date 06 April 2022