Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparison of the Hemodynamic Indices during Skull-Pin Head-Holder Insertion in Neurosurgeries in Two Groups Receiving Dexmedetomidine and Midazolam

Document Type : Original Article (s)

Authors
Mehrdad Masoudifar 1
Mohammad Hossein Amini-Tehrani 2
Parviz Kashefi 3
1 Associate Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Ira
2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v38i597.12087
Abstract
Background: This study aimed to compare the hemodynamic effects of dexmedetomidine and midazolam in neurosurgery candidates who underwent skull-pin head-holder insertion.Methods: In this randomized clinical trial study, 68 patients candidate for neurosurgery were divided into two groups receiving dexmedetomidine or midazolam. After induction of anesthesia, the patients received dexmedetomidine or midazolam based on the group they allocated to. Ten minutes after induction of anesthesia, the surgeon was allowed to insert the skull-pin head-holder. Hemodynamic variables were recorded before and during the surgery.Findings: Among 68 studied patients, there was significant difference between the groups regarding systolic blood pressure (P < 0.001), diastolic blood pressure (P = 0.002), mean blood pressure (P = 0.450), and heart rate (P = 0.003). Systolic, diastolic, and mean blood pressure in the midazolam group was significantly higher at first, second, and third minute after the insertion of the skull-pin head-holder in comparison with the dexmedetomidine group. Moreover, the heart rate was significantly higher in the midazolam group before inserting the skull-pin head-holder up to 3 minutes after the insertion in comparison with the dexmedetomidine group (P < 0.050).Conclusion: Compared with midazolam, dexmedetomidine showed a more significant effect on stabilizing hemodynamic parameters during craniotomies that required skull-pin head-holder insertion. Besides, the need for hemodynamic control drugs was lower after the administration of dexmedetomidine.
Keywords
Craniotomy
Dexmedetomidine
Neurosurgery
Midazolam
Hemodynamics
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Journal of Isfahan Medical School
Volume 38, Issue 597 - Serial Number 597
September and October 2021
Pages 790-797

  • Receive Date 27 July 2019
  • Accept Date 06 April 2022