The Effects of Conjugated Linoleic acid on Serum Fatty Acids Composition and Lipid Profile in Patients with Rectal Cancer Undergoing Chemoradiotherapy

Document Type : Original Article (s)

Authors

1 Professor, Nutrition Research Center AND Department of Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran

2 Associate Professor, Department of Radiotherapy, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

3 Assistant Professor, Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Background: Due to the importance of controlling recurrence of colorectal cancer, the effect of serum lipid profile and the fatty acid composition of cancer cell membranes on the response to treatment and survival, and the lack of clinical study on the effect of conjugated linoleic acid supplementation (CLA) in these patients, this study investigated the effect of CLA supplementation on serum fatty acid pattern, lipid profiles, and carcinoembryonic antigen (CEA) tumor marker in patients with rectal cancer treated with preoperative chemotherapy.Methods: In this randomized double-blind placebo-controlled pilot study, 31 patients with rectal cancer undergoing chemoradiotherapy assigned into the CLA group (n = 15), receiving 3 g CLA/d, and placebo group (n = 16) receiving placebo capsules for 6 weeks. Before and after intervention, serum fatty acid pattern, triglyceride, cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and CEA were evaluated.Findings: In placebo group, CLA supplementation increased the percentage of serum CLA (P = 0.35). CLA supplementation increased alpha linolenic acid (P = 0.01) significantly, and decreased the total omega-6 fatty acids and the omega-6 to omega-3 ratio. As compare with placebo, CLA supplementation had no significant effect on lipid profiles (P > 0.05).Conclusion: Considering the positive effects of CLA on omega-3 fatty acids, and to our knowledge, this is the first study that assess the effect of CLA supplementation; further studies with larger sample size are needed to generalize findings of this study.

Keywords

References

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Journal of Isfahan Medical School
Volume 38, Issue 606 - Serial Number 606
November and December 2021
Pages 996-1003

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History

  • Receive Date: 26 December 2020
  • Revise Date: 19 April 2024
  • Accept Date: 06 April 2022

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