The Effect of Intense Continuous and Interval Training on the Levels of Brain-Derived Neurotrophic Factor (BDNF) and Tumor Necrosis Factor Alpha (TNF- α) in Hippocampus of Old Rats

Document Type : Original Article (s)

Authors

1 Department of Physical Education and Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran

2 Assistant Professor, Department of Physical Education and Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran

3 Assistant Professor, Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran

Abstract

Background: The present study aimed to evaluate the effect of intense continuous and interval training on the levels of Brain-Derived Neurotrophic Factor (BDNF) and Tumor Necrosis Factor Alpha (TNF-α) in hippocampus of old rats.Methods: 30 old male Wistar rats (18 weeks old) were divided into 3 groups of interval training, continuous training, and control. Continuous training was performed for 8 weeks with 65% to 70% VO2max and interval training was performed 8 weeks with 5-8 repetitions of 2 minutes of working with 80%-100% VO2max and 2 minutes active rest with 50% of VO2max. Hippocampal samples were extracted 48 hours after the last training session to measure protein levels of BDNF and TNF-α. One-way ANOVA and Tukey post hoc tests were used for data analysis.Findings: Hippocampus BDNF levels in continuous (P = 0.002) and interval training (P = 0.003) groups were significantly higher than the control group. But no significant differences were found in BDNF levels between continuous and interval training groups (P = 0.361). TNF-α levels in continuous and interval training groups were significantly higher than the control group (P = 0.001 for both). But no significant differences were found in TNF-α levels between continuous and interval training groups (P = 0.639).Conclusion: Intense continuous and interval training increase BDNF levels in the hippocampus of the elderly rats through increasing TNF-α levels; thus, intense continuous and interval training can prevent aging of the nervous system by improving BDNF levels.

Keywords

References

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History

  • Receive Date: 24 April 2021
  • Revise Date: 08 May 2024
  • Accept Date: 06 April 2022

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