Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Comparison of the Effects of Fentanyl and Dexmedetomidine on Hemodynamic Stability in Patients undergoing Stereotactic Surgery

Authors
Mehrdad Masoudifar 1
Mina Foroghi 2
Taghi Hashemi 1
1 Assistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 General Practitioner, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.2022.16288
Abstract
Background: In patients undergoing surgery, hemodynamic disorders are common. Therefore, we decided to compare the effects of fentanyl and dexmedetomidine on hemodynamic changes in patients undergoing Stereotactic surgery. 
Methods: In this double blinded clinical trial, 68 candidates for Stereotactic Surgery in Alzahra Hospital in 2017 enrolled in the study. Patients were randomly divided into two groups; the first group was given bolus of 2 μg / kg fentanyl, and in the second group a loading dose of 1 μgr / kg / 10 min, followed by maintenance dose of: 0.5 μg / kg / h of dexmedetomidine was admininstered intravenously. The Dexmedetomidine was infused immediately 
following anesthesia induction. The hemodynamic variables in the two groups were evaluated.
Findings: There was no significant difference between the two groups based on systolic and diastolic blood pressure and oxygen saturation at different times. The heart rate in the dexmedetomidine group at 30, 60 and 90 minutes was significantly lower than fentanyl. On the other hand, there was no significant difference between the two groups with regards to pH, Pco2 and HCO3 before and after operation and recovery time.
Conclusion: Both dexmedetomidine and fentanyl are two effective drugs for controlling hemodynamics parameters in patients undergoing stereotactic surgery, but dexmedetomidine drug reduces heart rate significantly compared with fentanyl.
Keywords
Stereotaxic techniques
Hemodynamics
Dexmedetomidine
Fentany
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Journal of Isfahan Medical School
Volume 40, Issue 659
3rd Week, April
March and April 2022
Pages 48-54

  • Receive Date 14 April 2022