Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparison of Ketamine and Paracetamol in Addition to Morphine on Post-operative Pain Intensity after Laminectomy

Document Type : Original Article (s)

Authors
Golnaz Nosoohi 1
Kamran Tavakkol 2
Pirooz Basiri 3
Atena Khayambashi 4
Mehdi Izadi-Zamanabadi 5
1 General Practitioner, Najaf Abad University of Medical Sciences, Isfahan, Iran
2 Anesthesiology Expert, Assistant Professor, Department of Anesthesiology, Najaf Abad University of Medical Sciences, Isfahan, Iran
3 Anesthesiology Expert, Department of Anesthesiology, Najaf Abad University of Medical Sciences, Isfahan, Iran
4 Obstetrics and Gynecology Expert, Department of Obstetrics and Gynecology, University of Medical Sciences, Isfahan, Iran
5 Anesthesiology Expert, Department of Anesthesiology, University of Medical Sciences, Isfahan, Iran
10.48305/jims.v40.i676.0443
Abstract
Background: There have been several studies of postoperative pain control, but studies comparing paracetamol and ketamine on postoperative pain control have been limited. The purpose of this study is to compare the effects of ketamine and paracetamol on pain intensity after laminectomy through Patient-Controlled Analgesia pump (PCA).
Methods: This clinical trial was performed on two groups of 45 patients who were candidates for laminectomy. After laminectomy, patients in groups 1 and 2 were treated with (paracetamol + morphine) and (ketamine + morphine) by PCA pump, respectively. Pain intensity and the prevalence of nausea and vomiting in the two groups were assessed.
Findings: Pain intensity decreased significantly in both groups over time; But the mean pain intensity in the ketamine group during 6, 12, 18 and 24 hours after surgery was significantly lower than the paracetamol group. While 11.1% of patients in paracetamol group and 28.9% of patients in ketamine group experienced nausea and vomiting after administration of analgesia.
Conclusion: This study showed that in patients undergoing laminectomy, combining (ketamine + morphine) has significantly led to better pain relief effects than with the combination of (paracetamol + morphine) in PCA pump. However, the incidence of side effects is higher in this group.
Keywords
Ketamine
Acetaminophen
Post-operative pain
Laminectomy
Infusion pump
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Journal of Isfahan Medical School
Volume 40, Issue 676
4th Week, August
July and August 2022
Pages 443-450

  • Receive Date 26 February 2022
  • Revise Date 23 August 2022
  • Accept Date 29 May 2022