Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Relationship between Programmed Cell Death Receptor-1 Expression in Colon Tumoral Tissue and Clinical and Pathological Characteristics of Patients with Colon Cancer

Document Type : Original Article(s)

Authors
Zahra Mokhtari 1
Marzieh Rezaei 2
Mohammad Hossein Sanei 3
Zahra Faghih 4
1 Medical Student, Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Associate Professor, Institute for Cancer Research (ICR), School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
10.48305/jims.v41.i706.0027
Abstract
Background: Activatory or inhibitory immune checkpoints regulate the activity of the immune system. Programmed cell death receptor 1 (PD-1 is an inhibitory immune checkpoint that their overexpression reflects the exhaustion of the immune system. However, it is still unclear how it affects the prognosis of colorectal cancer (CRC). This study aimed to investigate the prognostic value of PD-1 in patients with CRC according to tumor location.
Methods: In a cross-sectional study during 2020-2021, a number of 136 patients with history of CRC who underwent surgery at Al-Zahra Hospital in Isfahan between 2013 and 2017 were selected and evaluated retrospectively. Immuno-histochemical staining of tissue samples was performed for PD-1 marker and the expression of this marker was determined in the center and invasive margins of the tumor. Data on survival and date of death of patients were completed through the patient file and confirmed through the civil registry.
Findings: High expression of PD-1 in invasive margin was significantly related to lower T stage (T1/2) in left tumors, low M stage (M0) in right tumors, absence of metastasis in right and left tumors, larger tumor size
(≥ 5 cm) in right-sided tumors. The expression of this marker in any tumor areas was not significantly related to the survival of the patients.
Conclusion: The findings of this study showed that high expression of PD-1 is related to the lower stages of the CRC, but it is not a good indicator for the prognosis of patients with colon cancer.
Keywords
Colorectal cancer
Immune checkpoint proteins
Immunohistochemistry
prognosis
Programmed Cell Death 1 Receptor

Subjects

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Journal of Isfahan Medical School
Volume 41, Issue 706
2nd Week, April
March and April 2023
Pages 27-34

  • Receive Date 09 November 2022
  • Revise Date 13 March 2023
  • Accept Date 14 March 2023