Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effects of Eight Weeks of Aerobic Exercise on Plasma Nesfatin-1, Insulin, Glucose and Insulin Resistance in Obese Women

Document Type : Original Article(s)

Authors
Abdolreza Kazemi 1
Hadi Kerendi 2
Monavareh Iranmanesh 3
1 Associate Professor, Department of Sports Science, School of Literature and Humanities, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran
2 PhD in Exercise Physiology, Department of Physical Education and Sports Sciences, School of Literature and Humanities, Lorestan University, Khorramabad, Iran
3 Master of Sports Physiology, Department of Sports Sciences, School of Literature and Humanities, Islamic Azad University, Kerman Branch, Kerman, Iran
10.48305/jims.v41.i709.0110
Abstract
Background: Obesity is associated with increase the risk of metabolic diseases including type 2 diabetes. On the other hand, aerobic exercise training can play a positive role in preventing metabolic diseases. The aim of the present study was to investigate the effects of 8 weeks of aerobic exercise training on plasma nesfatin-1, insulin, and glucose and insulin-resistance in obese women.
Methods: The present study was a Semi-experimental-study. Twenty-tow obese women (age 25 ± 2 years and body mass index 30 ± 3.1) were randomly selected from obese women referred to Kerman clubs and randomly assigned to experimental (n = 11) and control (n = 11) groups. Aerobic exercise was including 30 minutes of running based on 50-70% of target heart rate for 8 weeks and 3 days a week performed by the experimental group. The desired variables were measured before and after the exercise protocol. The ANCOVA test was used to analyze the data.
Findings: A non-significant-difference was observed in the weight and BMI at the end of the research. Also this study showed no significant difference between the experimental and control groups in Nesfatin-1. The levels of insulin, glucose and insulin-resistance were significantly lower in the experimental group compared to the control. In addition, aerobic exercise decreased body fat percentage and increased Vo2max in the experimental group compared to the control.
Conclusion: According to the results, it is suggested that obese women use aerobic exercises in order to improve their body fat percentage, aerobic capacity and indicators related to diabetes.
Keywords
Adipokines
Exercise training
Insulin resistance
Obesity
  1. Lobstein T, Brinsden H, Neveux M. World obesity atlas 2022; 2022.
  2. Cercato LM, White PA, Nampo FK, Santos MR, Camargo EA. A systematic review of medicinal plants used for weight loss in Brazil: Is there potential for obesity treatment? J Ethnopharmacol 2015; 176: 286-96.
  3. Hosseini-Esfahani F, Bahadoran Z, Moslehi N, Asghari G, Yuzbashian E, Hosseinpour-Niazi S, et al. Metabolic syndrome: findings from 20 years of the Tehran lipid and glucose study. Int J Endocrinol Metab 2018; 16(4 Suppl): e84771.
  4. Blanco AM. Hypothalamic-and pituitary-derived growth and reproductive hormones and the control of energy balance in fish. Gen Comp Endocrinol 2020; 287: 113322.
  5. Myers MG. Keeping the fat off with nesfatin. Nat Med 2006; 12(11): 1248-9.
  6. Taji Tabas A, Mogharnasi M. The effect of 10 week resistance exercise training on serum levels of nesfatin-1 and insulin resistance index in woman with type 2 diabetes [in Persian]. IJDM 2015; 14(3): 179-88.
  7. Yaribeygi H, Atkin SL, Simental-Mendía LE, Sahebkar A. Molecular mechanisms by which aerobic exercise induces insulin sensitivity. J Cell Physiol 2019; 234(8): 12385-92.
  8. Thaane T, Motala AA, Mckune AJ. Lifestyle modification in the management of insulin resistance states in overweight/obesity: the role of exercise training. JEMDSA 2019; 24(2): 65-9.
  9. Wedell-Neergaard A-S, Lehrskov LL, Christensen RH, Legaard GE, Dorph E, Larsen MK, et al. Exercise-induced changes in visceral adipose tissue mass are regulated by IL-6 signaling: a randomized controlled trial. Cell Metab 2019; 29(4): 844-55.e3.
  10. Tofighi A, Mehrabani J, Khadivi SM. The effect of 8 weeks aerobic exercise on Nesfatin-1 and acylated Ghrelin in young obese men [in Persian]. Med J Mashhad Univ Med Sci 2014; 57(3): 562-70.
  11. Mogharnasi M, TaheriChadorneshin H, Papoli-Baravati SA, Teymuri A. Effects of upper-body resistance exercise training on serum nesfatin-1 level, insulin resistance, and body composition in obese paraplegic men. Disabil Health J 2019; 12(1): 29-34.
  12. Aghapour A, Farzanegi P. Effect of six-week aerobic exercise on Chemerin and Resistin concentration in hypertensive postmenopausal women: Array. Electron Physician 2013; 5(1): 623-30.
  13. Kazemi AR, Imani M, Banitalebi E. An investigation of the effects of the 8-week intense interval training and combined strength-endurance training on secreted protein acidic and rich in cysteine (SPARC) levels in women with type 2 diabetes [in Persian]. Community Health J 2018; 12(2): 47-56.
  14. Bagheri L, Faramarzi M, Banitalebi E, Azamian Jazi A. Anabolic hormonal adaptation after different order of concurrent training in older women [in Persian].
    J Sport Biomotor Sci 2015; 6(12): 15-28.
  15. Soori R, Mahmoodi F, Ramezankhani A, Ranjbar K. Effect of 12 weeks resistance training on nesfatn-1 and neuropeptide Y hormones in sedentary obese men [in Persian]. JPSBS 2019; 7(13): 99-111.
  16. Arıkan S. Effects of acute and chronic exercises on plasma nesfatin-1 levels in young adults. Cyprus J Med Sci 2020; 5(1): 77-80.
  17. Karajibani M, Montazerifar F, Dehghani K,
    Mogharnesi M, Mousavi Gilani SR, Dasheipour A. Effect of 10 weeks of speed and endurance exercise and a period of detraining on serum nesfatin-1, lipid profiles, body fat percentage and Body mass index in non-athlete healthy men. JPSBS 2019; 7(14): 129-40.
  18. Koroni R, Yonesyan A, Donyaei A. Comparison of the effect of 8 weeks of different exercises (endurance, resistance and combined) on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes [in Persian]. JAHSSP 2023; 10(1): 83-96.
  19. Chaolu H, Asakawa A, Ushikai M, Li YX, Cheng KC, Li JB, et al. Effect of exercise and high-fat diet on plasma adiponectin and nesfatin levels in mice. Exp Ther Med 2011; 2(2): 369-73.
  20. Amanat S, Sinaei E, Panji M, MohammadporHodki R, Bagheri-Hosseinabadi Z, Asadimehr H, et al. A randomized controlled trial on the effects of 12 weeks of aerobic, resistance, and combined exercises training on the serum levels of nesfatin-1, irisin-1 and HOMA-IR. Front Physiol 2020; 11: 562895.
  21. Mogharnasi M, TaheriChadorneshin H, Abbasi-Deloei N. Effect of exercise training type on plasma levels of vaspin, nesfatin-1, and high-sensitivity C-reactive protein in overweight and obese women. Obes Med 2019; 13: 34-8.
  22. Ahmadizad S, Salimi Avansar A, Ebrahim K, Avandi M, Ghasemikaram M. The effects of short-term high-intensity interval training vs. moderate-intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers. Horm Mol Biol Clin Investig 2015; 21(3): 165-73.
  23. Donges C, Duffield R, Drinkwater E. Effect of resistance or aerobic exercise training on interleukin-6, C-reactive protein, and body. Med Sci Sports Exerc 2010; 42(2): 304-13.
  24. Ramzany N, Gaeini A, Choobineh S, Kordi M, Hedayati M. Changes of RBP-4 and insulin resistance after 8 weeks of aerobic training in type 2 diabetic rats [in Persian]. Metab Exerc 2017; 5(2): 89-98.
  25. Motallebi F, Shakerian S, Ranjbar R. Effect of 8 weeks aerobic interval training on glycosylated hemoglobin and insulin resistance index in diabetic mellitus Type 2 women [in Persian]. Intern Med Today 2016; 22(2): 137-43.
  26. Le S, Mao L, Lu D, Yang Y, Tan X, Wiklund P, et al. Effect of aerobic exercise on insulin resistance and central adiposity disappeared after the discontinuation of intervention in overweight women. J Sport Health Sci 2016; 5(2): 166-70.
  27. Nesreen N, Mohsen ES, Omar NN. Moderate exercise training has anorexogenic effect associated with improved oxidative stress in obese women. IJNAM 2015; 7(4): 52-61.
  28. Yazici AG. Relationship and interaction between anaerobic sports branches and serum nesfatin-1. Turk J Phys Med Rehab 2015; 61: 234-40.
  29. Saghebjoo M, Dastigerdi S, Afzalpour ME, Hedayati M. Effects of aerobic and resistance training on plasma visfatin levels in overweight women [in Persian]. Koomesh 2012; 13(2): 225-32.
  30. Gibson AL, Wagner D, Heyward V. Advanced fitness assessment and exercise prescription. 8th Champaign, Illinois: Human Kinetics; 2019.

 

Journal of Isfahan Medical School
Volume 41, Issue 709
1st Week, May
May and June 2023
Pages 110-117

  • Receive Date 06 December 2022
  • Accept Date 03 April 2023