Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparison of the Effect of Resistance-Endurance Training on the Number of Osteocyte, Osteoblast, and Osteoclast Cells in Femur Bone Tissue in Adult, Child, and Elderly Male Rats

Document Type : Original Article (s)

Authors
Mahshid Shiri 1
Mohammad Reza Fadaei Chafy 2
Shahram Gholamrezaei 2
1 PhD Candidate of Exercise Physiology, Department of Physical Education and Sport Science, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran
2 Assistant Professor, Department of Physical Education and Sport Science, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran
10.48305/jims.v41.i734.0764
Abstract
Background: Although exercise is known as an effective factor in maintaining and improving bone strength; it is not clear that its effects on bone-forming and bone-eating cells of different age groups are the same. Therefore, this study aimed to investigate the effect of resistance-endurance training on the number of osteocyte, osteoblast, and osteoclast cells in femur bone tissue in male rats of different ages.
Methods: In the present study, 30 male Wistar rats in three age groups of 2 weeks, 6 weeks, and 96 weeks were randomly divided into 2 groups of 5 each, training and control. Resistance-endurance exercises were performed for 6 training sessions per week for 6 weeks. Rats were sacrificed under carbon dioxide gas. H&E staining was used for tissue microscopic examination.
Findings: The results of one-way analysis of variance with Tukey's post hoc test showed that higher amounts of osteoblast and osteocyte cells and lower amounts of osteoclast cells in trained rats of all three age groups were significant compared to their control group. The comparison of exercise groups showed that the number of osteoblasts in the child and adult groups, the number of osteocytes in the adult group, and the number of osteoclasts in the adult and elderly groups were higher.
Conclusion: The results showed that resistance-endurance training led to an increase in bone-forming cells and a decrease in bone-eating cells. However, the effects of exercise on bone formation in younger age groups were more than in old age. Nevertheless, the prevention of exercise from the process of bone loss in older age, especially old age, was evident.

Highlights

Mahshid Shiri: Google Scholar

Mohammad Reza Fadaei Chafy: Google Scholar

Shahram Gholamrezaei: Google Scholar

Keywords
Strength exercise
Aerobic exercise
Osteocyte
Osteoblast
Osteoclast
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Journal of Isfahan Medical School
Volume 41, Issue 734
2nd Week, November
November and December 2023
Pages 764-772

  • Receive Date 04 May 2023
  • Accept Date 24 October 2023