Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of Zinc and Selenium Supplements on the Prevalence of Atrial Fibrillation after Coronary Artery Bypass Surgery: A Randomized Clinical Trial Study

Document Type : Original Article(s)

Authors
Mehran Shahzamani 1
Alireza Hoseini 1
Elham Kiani 2
1 Associate Professor, Department of Anesthesiology, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 MSc of Perfusion, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v42.i754.0035
Abstract
Background: This study was conducted to determine the effect of zinc and selenium supplements on the incidence of atrial fibrillation after coronary artery bypass surgery.
Methods: In this clinical trial, 54 patients were randomly divided into two groups of 27. The intervention group received a daily capsule containing 200 micrograms of zinc and 15 mg of selenium a week before the operation, and the control group received a placebo. 24 hours before the operation, the zinc and selenium levels were checked. All patients after surgery were examined and compared in terms of clinical parameters including atrial fibrillation, cardiac ejection fraction, bleeding, and length of hospitalization in the intensive care unit and hospital.
Findings: The mean difference of cardiac ejection fraction in the intervention group was -2.41 ± 0.77% (increased) and in the control group was 2.78 ± 0.86% (decreased), and the difference between the two groups was significant (P < 0.001). During the study, 4 (14.8%) of the control group had ventricular fibrillation, and there was no case of AF in the intervention group, and the difference between the two groups was significant
(P = 0.015). The mean volume of bleeding (P = 0.011) and the mean length of hospital stay were significantly different between the two groups.
Conclusion: Prescribing zinc and selenium supplements before coronary artery bypass surgery can lead to a more favorable prognosis and reduce the incidence of ventricular fibrillation, reduce the length of hospital stay, and reduce the amount of bleeding after surgery.

Highlights

Mehran Shahzamani: Google Scholar, PubMed

Alireza Hoseini: Google Scholar, PubMed

Keywords
Cardiac surgical procedures
Zinc
Selenium
Atrial fibrillation

Subjects

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Journal of Isfahan Medical School
Volume 42, Issue 754
2nd Week, April
March and April 2024
Pages 35-42

  • Receive Date 14 September 2023
  • Accept Date 18 February 2024