Document Type : Original Article(s)
Authors
1
Associate Professor, Department of Immunology, School of Medicine,, Sabzevar University of Medical Sciences, Sabzevar, Iran
2
Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran
3
Department of Radiology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran. Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.
4
Department of Internal Medicine, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran. Leishmaniasis Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
5
Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
10.48305/jims.2024.42409.1802
Abstract
Background: COVID-19 is an infectious disease that often affects the lungs, and its symptoms can range from a simple cold to multiple organ failure and death. It is very important to have a fast, simple and reliable method to help diagnose the disease and start the treatment. The aim of this study was to compare some inflammatory indices in COVID-19 patients with different degrees of lung involvement.
Methods: In this descriptive-analytical study, 301 patients with COVID-19 who were hospitalized in Vasei-Sabzevar Hospital from October 2021 to March 2022 were included. Patients were divided into mild, moderate and severe groups based on the CT-scan findings and the severity of lung involvement. Based on complete blood count (CBC) results, neutrophil/lymphocyte(NLR), monocyte/lymphocyte(MLR), platelet/lymphocyte(PLR) ratios, and systemic inflammation index(SII) were calculated.
Findings: Based on CT-scan findings, mild, moderate and severe lung involvement was observed in 39%, 37% and 24% of patients, respectively. NLR, PLR and SII indices were significantly higher in severe lung involvement compared to other groups (P<0.05). The MLR was significantly higher in severe lung involvement than moderate involvement. Mortality in severe lung involvement was significantly higher than moderate and mild groups(41% vs. 2% and 5%, respectively) (P<0.001). Also, 13% of patients died. there was no significant difference between mortality and patients gender.
Conclusion: NLR, PLR, MLR, and SII are related to COVID-19 severity and these indices amounts in severe lung involvement are more than moderate and mild involvement. These findings show the importance of these indices in determining the COVID-19 prognosis.
Highlights
Mohammad-Shafi Mojadadi: Google Scholar, PubMed
Mohammad Reza Aram: Google Scholar, PubMed
Ramin Shahraini: Google Scholar, PubMed
Abolfazl Shakiba: Google Scholar, PubMed
Saeideh Sadat Shobeiri: Google Scholar, PubMed
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