Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparison of the Effect of Running and Swimming on Some Liver Enzymes of Male Rats Induced by Doxorubicin

Document Type : Original Article(s)

Authors
Gholamhasan Jafarzadeh 1
Azadeh Zamani Behbahani 2
Mehdi Yaghmaei 3
Mohammad Salehi Veisi 4
1 Faculty Member of Behbahan Khatam Alanbia University of Technology, Behbahan, Iran
2 Behbahan Faculty of Medical Science, Behbahan, Iran
3 Behbahan Khatam Alanbia University of Technology, Behabahan, Iran
4 Department of Statistics, Faculty of Data and Energy Sciences Behbahan Khatam Alanbia University of Technology, Behabahan, Iran
10.48305/jims.v42.i762.0248
Abstract
Background: Various exercises have been studied to reduce the complications caused by the use of doxorubicin and other chemotherapy drugs on healthy body organs; But a limited number of these studies have compared the effect of different sports programs; Therefore, the aim of this study is to compare running and swimming on some liver enzymes of rats induced by doxorubicin.
Methods: 36 adult male desert mice weighing 230 to 280 grams were randomly divided into 6 groups of 6: resting sham (SH), treadmill sham (SHT), swimming sham (SHS), doxorubicin rest (D), doxorubicin treadmill (DT), doxorubicin swimming (DS) were divided. The sports groups did the exercise program 5 sessions a week for 6 weeks. 24 hours after the last exercise session, blood was taken from the left ventricle of the animal with a syringe. To analyze the data, descriptive analysis and one-way analysis of variance, ANOVA and Tukey's post hoc test at a significance level of 0.05.
Findings: Doxorubicin injection caused a significant increase in ALP, SGPT, and SGOT enzymes, both running and swimming exercises caused a significant decrease in ALP, SGPT, and SGOT enzymes, but there was no significant difference between the running and swimming groups on the reduction of the studied enzymes.
Conclusion: Based on the results of the present study, it seems that endurance sports activities are a good way to reduce hepatotoxicity caused by doxorubicin injection in cancer patients, and none of the swimming and running exercises are preferable to the other.
Keywords
Running
Swimming
Liver enzymes
Doxorubicin

Subjects

  1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015; 65(1): 5-29.
  2. Li M, Xiong Z-G. Ion channels as targets for cancer therapy. Int J Physiol Pathophysiol Pharmacol 2011; 3(2): 156-66.
  3. Kavazis AN, Smuder AJ, Min K, Tümer N, Powers SK. Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72. Am J Physiol Circ Physiol 2010; 299(5): H1515-24.
  4. Spain L, Diem S, Larkin J. Management of toxicities of immune checkpoint inhibitors. Cancer Treat Rev 2016; 44: 51-60.
  5. Kaur J, Singla S, Kumar N. In vivo studies on the protective effect of propolis on doxorubicin-induced toxicity in liver of male rats. Toxicol Int 2014; 21(2): 191-5.
  6. Costa Godinho LRL, Cella PS, Guimarães TAS, Palma GHD, Nunes JHC, Deminice R. Creatine supplementation potentiates exercise protective effects against doxorubicin-induced hepatotoxicity in mice. Antioxidants (Basel) 2023; 12(4): 823.
  7. Cheung KG, Cole LK, Xiang B, Chen K, Ma X, Myal Y, et al. Sirtuin-3 (SIRT3) Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes. J Biol Chem 2015; 290(17): 10981-93.
  8. Ascensão A, Oliveira PJ, Magalhães J. Exercise as a beneficial adjunct therapy during Doxorubicin treatment—Role of mitochondria in cardioprotection. Int J Cardiol 2012; 156(1): 4-10.
  9. Alhowail AH, Pinky PD, Eggert M, Bloemer J, Woodie LN, Buabeid MA, et al. Doxorubicin induces dysregulation of AMPA receptor and impairs hippocampal synaptic plasticity leading to learning and memory deficits. Heliyon 2021; 7(7): e07456.
  10. Zolfagharzadeh F, Roshan VD. Pretreatment hepatoprotective effect of regular aerobic training against hepatic toxicity induced by doxorubicin in rats. Asian Pacific J Cancer Prev 2013; 14(5): 2931-6.
  11. Calvé A, Haddad R, Barama S-N, Meilleur M, Sebag IA, Chalifour LE. Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training. Am J Physiol Circ Physiol 2012; 302(10): H2048-57.
  12. Jafarzadeh G, Shakeryan S, Farbood Y, Ghanbarzadeh M. Effects of eight weeks of resistance exercises on expression of neurotrophins and trk receptors in alzheimer model male wistar rats. Basic Clin Neurosci J 2021; 2(3): 349-59.
  13. Taskin E, Dursun N. Recovery of adriamycin induced mitochondrial dysfunction in liver by selenium. Cytotechnology 2015; 67(6): 977-86.
  14. Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol 2013; 65(2): 157-70.
  15. Boeno FP, Patel J, Montalvo RN, Lapierre-Nguyen SS, Schreiber CM, Smuder AJ. Effects of exercise preconditioning on doxorubicin-induced liver and kidney toxicity in male and female rats. Int J Mol Sci 2023; 24(12): 10222.
  16. Hinkley JM, Morton AB, Ichinoseki-Sekine N, Huertas AM, Smuder AJ. Exercise Training prevents doxorubicin-induced mitochondrial dysfunction of the liver. Med Sci Sport Exerc 2019; 51(6): 1106-15.
  17. Min K, Kwon O, Smuder AJ, Wiggs MP, Sollanek KJ, Christou DD, et al. Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin‐induced cardiac and skeletal muscle myopathy. J Physiol 2015; 593(8): 2017-36.
  18. Gilliam LAA, Lark DS, Reese LR, Torres MJ, Ryan TE, Lin C-T, et al. Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction. Am J Physiol Metab 2016; 311(2): E293-301.
  19. Hashemi Chashemi SZ, Hojati SS, Dabidiroshan V, Jalali Dehkordi K. The role of exercise in adaptation and body response to doxorubicin-induced cellular toxicity: a narrative review study [in Persian]. J Rafsanjan Univ Med Sci 2020; 19(8): 869-88.
Journal of Isfahan Medical School
Volume 42, Issue 762
2nd Week, June
May and June 2024
Pages 248-255

  • Receive Date 03 July 2024
  • Accept Date 09 July 2024