Journal of Isfahan Medical School

Journal of Isfahan Medical School

Epidemiological and Histopathological Feature of Gastric Cancer in Patients from Isfahan between 2015 and 2019

Document Type : Original Article (s)

Authors
Vahid Zarghami 1
Zahra Ravankhah 2
Mehran Sharifi 3
Mehrdad Zeinalian 4
1 General Practitioner, School of Medicine, Isfahan University of Medical Sciences, Iran
2 General Practitioner, Department of Prevention of Non-Communicable Diseases, Vice-Chancellor of Health, Isfahan University of Medical Sciences, Iran
3 Hematology and Adult Cancer Specialist, Assistant Professor of Internal Medicine Department, School of Medicine, Isfahan University of Medical Sciences, Iran
4 Assistant Professor, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Iran
10.48305/jims.v43.i817.0582
Abstract
Background: Gastric cancer is one of the most common malignancies in Iran and worldwide and one of the deadliest diseases in the world. Therefore, identifying the epidemiological aspects of this disease is one of the main tools to deal with it. In this study, we examined the epidemiological and histopathological features of gastric cancer in Isfahan province from 2015 to 2019.
Methods: This study is a cross-sectional descriptive research and the data were collected from the database of the Non-Communicable Diseases Prevention group of the university health department and analyzed using qualitative and quantitative statistical methods.
Findings: According to the findings obtained in 5 years of data analysis, the number of new cases of stomach cancer in Isfahan province was 2438 and the average incidence rate over these 5 years was 10.24; Of these, 67.8% were men and 32.2% were women. The mean age at diagnosis was 65.85 years. The most common type of tumor was adenocarcinoma. Also, Khwansar city had the highest and Borkhar city had the lowest incidence of stomach cancer.
Conclusion: The incidence rate of gastric cancer in Isfahan province varied during the 2015-2019 period; However, it seems that the incidence of this disease has increased in younger ages, especially in women. Therefore, preventive measures and early detection through screenings are suggested.

Highlights

Mehrdad Zeinalian: Google Scholar

Keywords
Stomach neoplasm
Malignancy
Epidemiology
Pathology
Iran

Subjects

  1. Asmarian NS, Kavousi A, Salehi M, Mahaki B. Mapping of Stomach Cancer Rate in Iran Using Area-to-Area Poisson Kriging [in Persian]. J Health Syst Res 2012; 8(4): 681-7.
  2. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71(3): 209-49.
  3. Smyth EC, Nilsson M, Grabsch HI, van Grieken NC, Lordick F. Gastric cancer. Lancet. 2020 ;396(10251): 635-48.
  4. Kumar S, Metz DC, Ellenberg S, Kaplan DE, Goldberg DS. Risk factors and incidence of gastric cancer after detection of Helicobacter pylori infection: a large cohort study. Gastroenterology 2020; 158(3): 527-36. e7.
  5. Yaghoobi M, McNabb-Baltar J, Bijarchi R, Hunt RH. What is the quantitative risk of gastric cancer in the first-degree relatives of patients? A meta-analysis. World J Gastroenterol 2017; 23(13): 2435-42.
  6. Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer 2007; 10(2): 75-83.
  7. Alberts SR, Cervantes A, van de Velde CJH. Gastric cancer: epidemiology, pathology and treatment. Ann Oncol 2003; 14(Suppl 2): ii31-ii6.
  8. Yang L, Ying X, Liu S, Lyu G, Xu Z, Zhang X, et al. Gastric cancer: Epidemiology, risk factors and prevention strategies. Chin J Cancer Res 2020; 32(6): 695-704.
  9. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68(6): 394-424.
  10. Akhondzadeh E, Yavari P, Mehrabi Y, Kabir A. Estimates of One, Three, and Five Year Survival Rate of Patients with Gastric Cancer in Iran Using the Meta-Analysis Method [in Persian]. Iranian J Epidemiol 2015; 11(1): 1-12.
  11. Zende Del K, Marzban M, Jafari N, Nahvijo A, Mohagheghi MA. Geographic pattern of attenuation rates and epidemiology of gastric cancer in Iran [in Persian]. Journal of Knowledge and Health in basic Medical Sciences 2015; 5: 63.
  12. Moradian F, Fararouei M, Karami M, Ghelichi-Ghojogh M, Gheibi Z, Nikeghbalian Z, et al. Trend of geographical distribution of stomach cancer in Iran from 2004 to 2014. BMC gastroenterol 2022; 22(1): 4.
  13. World Health Organization. International classification of diseases for oncology (ICD-O). World Health Organization; 2013.
  14. Karimi P, Islami F, Anandasabapathy S, Freedman ND, Kamangar F. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev 2014; 23(5): 700-13.
  15. Arnold M, Park JY, Camargo MC, Lunet N, Forman D, Soerjomataram I. Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035. Gut 2020; 69(5): 823-29.
  16. Moradzadeh R, Nadrian H, Najafi A. Trend of gastric cancer in a province in Western Iran: A population-based study during 2001–2014. J Res Med Sci 2020; 25(1): 12.
  17. Alghamdi IG. Epidemiology of gastric cancer in Saudi Arabia from 2004 to 2017. Mol Clin Oncol 2023; 19(5): 93.
  18. Wong MC, Huang J, Chan PS, Choi P, Lao XQ, Chan SM, et al. Global incidence and mortality of gastric cancer, 1980-2018. JAMA Netw Open 2021;4(7): e2118457-e.
  19. Nourozinia F, Rasmi Y, Otarod M, Golizadeh M, Khadem-Ansari M-H. Epidemiology and histopathology of gastric cancer in Urmia [in Persian]. Studies in Medical Sciences 2013; 24(3): 170-5.
  20. Kalan Farmanfarma K, Mahdavifar N, Hassanipour S, Salehiniya H. Epidemiologic study of gastric cancer in Iran: a systematic review. Clin Exp Gastroenterol 2020; 13: 511-42.
  21. Sekiguchi M, Oda I, Matsuda T, Saito Y. Epidemiological trends and future perspectives of gastric cancer in Eastern Asia. Digestion 2022; 103(1): 22-8.
  22. Rajaiefard A, Moghimi B, Tabatabaie SH, Safaie A, Tabeie SZ. Epidemiological and clinical features of gastric cancer: descriptive study of cancer registry cases of Fars province (2001-2006). [in Persian] Iran South Med J 2011; 14(2): 114-21.
  23. Thrift AP, Nguyen TH. Gastric cancer epidemiology. Gastrointest Endosc Clin N Am 2021; 31(3): 425-39.
  24. Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol 2019; 14(1): 38-26.
  25. Hahn KY, Park CH, Lee YK, Chung H, Park JC, Shin SK, et al. Comparative study between endoscopic submucosal dissection and surgery in patients with early gastric cancer. Surg Endosc 2018; 32(1): 73-86.
  26. Almasi Z, Rafiemanesh H, Salehiniya H. Epidemiology characteristics and trends of incidence and morphology of stomach cancer in Iran. Asian Pac J Cancer Prev 2015; 16(7): 2757-61.
Journal of Isfahan Medical School
Volume 43, Issue 817
1st Week, August
July and August 2025
Pages 582-589

  • Receive Date 21 January 2025
  • Accept Date 19 July 2025