Abstract
Background: Hodgkin's lymphoma is a malignant neoplasm of B lymphocytes. The current study aimed to investigate the relationship between the site of involved lymph nodes and different subtypes of Hodgkin's lymphoma.
Methods: This is a cross-sectional study that was performed in 2014-2019 in Isfahan on medical documents of 249 patients with Hodgkin's lymphoma that underwent lymph node biopsy. The following information was gathered: subtypes of Hodgkin's lymphoma, site of lymph node involvement, types of procedures (core needle biopsy (CNB) or resection), and presence of CD15, CD20, or CD30 in the IHC staining.
Results: The most common subtype of Hodgkin's lymphoma was nodular sclerosis (46.2%), cervical lymph nodes were the most common involved sites (55.8%). Cervical, mediastinal, and supraclavicular lymph nodes were involved mostly by nodular sclerosis while axillary and inguinal lymph nodes and spleen were involved mostly by mixed cellularity. CD 15, CD20 and CD30 were positive in 71.6%, 57.8% and 92.2% of patients respectively
Conclusion: NSCHL and mixed cellularity were the most frequent subtypes that were more frequent among patients with 18-34 years and cervical and mediastinal lymph nodes.

Keywords: Hodgkin's lymphoma, lymphoma, lymph node.