Journal of Isfahan Medical School

Journal of Isfahan Medical School

The effect of different levels of physical activity on the regulation of chromogranin A and immunoglobulin A and the effect of these indicators on the immune system of adolescents

Document Type : Original Article(s)

Authors
Marzieh Sadat Azarniveh 1
Mitra Khademosharie 2
1 Assistant Professor, Department of Sport Sciences, Faculty of Literature and Humanities, University of Zabol, Zabol, Iran
2 Assistant Professor, Department of Physical Education, Faculty of Literature and Humanities, Kowsar University of Bojnourd, Bojnourd, Iran
10.48305/jims.v44.i851.0165
Abstract
Introduction: The immune system of adolescents is vulnerable due to changes associated with age and the influence of environmental factors. It has been determined that physical activity is one of the key factors in maintaining the physical and mental health of individuals in all age groups. Therefore, the aim of this study was to investigate the effect of different levels of physical activity on the regulation of chromogranin A and immunoglobulin A and the effect of these indicators on the immune system of adolescents.

Methods: This cross-sectional descriptive study included 60 boys aged 14 to 16 years old from Yazd Region 1 who participated voluntarily and were selected by simple sampling method. Participants were divided into three groups: inactive, active, and athlete (20 people in each group). The Baecke questionnaire was used to determine physical activity levels. Saliva samples were collected and analyzed using ELISA for biomarkers. Data analysis was performed using SPSS version 16, ANOVA test, and Bonferroni and James-Howell post hoc tests, considering a significance level of p ≤ 0.05.

Findings: The results of statistical analysis showed that there was a significant difference between the groups in the chromogranin A index (p<0.001) and it was significantly lower in the athletic and active groups than in the inactive group, and the greatest decrease was observed in the athletic group (p<0.001). However, no significant difference was observed between the groups for salivary immunoglobulin A (p=0.096).

Conclusion: Regular physical activity can reduce CgA levels and modulate physiological stress in adolescents, but

Highlights

Marzieh Sadat Azarniveh: Google Scholar, PubMed

Mitra Khademosharie: Google Scholar

Keywords
Exercise
Chromogranin A
Immunoglobulin A
Immune system
Saliva
Male Adolescents

Subjects

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Journal of Isfahan Medical School
Volume 44, Issue 851
3rd Week, April
March and April 2026
Pages 165-171

  • Receive Date 07 June 2025
  • Accept Date 13 May 2026