Journal of Isfahan Medical School

Journal of Isfahan Medical School

The relationship between coronary and venous sinus lactate level before and after cardiopulmonary bypass with mortality and postoperative complications

Document Type : Original Article(s)

Authors
Kavak Hejab 1
Mehran Shahzamani 2
1 Department of Cardiovascular Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor of Cardiovascular Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v44.i855.0374
Abstract
Background: The present study aimed to evaluate the relationship between coronary and venous sinus lactate level before and after cardiopulmonary bypass (CPB) with mortality and postoperative complications.
Methods: The present cross-sectional study was conducted on 32 CABG candidate patients referred to Chamran Hospital. Before the start of the operation, after the patients were placed on the surgical bed and venous and arterial lines were established and initial monitoring was performed, arterial and venous blood samples and coronary sinus were taken and lactate levels were examined. After the operation and after admission to the intensive care unit, lactate levels were also measured.
Findings: The venous lactate level of patients after CPB was significantly higher with a mean of 2.44±0.47 than before CPB with a mean of 1.64±0.68 (P value=0.006). Also, the coronary sinus lactate level after CPB was significantly higher with a mean of 2.27±0.86 than before CPB with a mean of 1.23±0.95 (P value<0.001). However, the venous and sinus lactate levels of these patients before and after CPB were not significantly different (P value>0.05). In addition, only the duration of hospitalization in the intensive care unit and hospital had a direct and significant relationship with the increase in lactate (venous or coronary sinus) (P value<0.05).
Conclusion: According to the results of this study, both venous and coronary sinus lactate levels significantly increased after CPB compared to before. However, the increase in lactate levels was only significantly associated with the duration of hospitalization in the intensive care unit and hospital.

Highlights

Kavak Hejab: Google Scholar, PubMed

Mehran Shahzamani: Google Scholar, PubMed

Keywords
Lactate
Cardiopulmonary Bypass
Mortality
Complications
Subjects
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Journal of Isfahan Medical School
Volume 44, Issue 855
3rd Week,May
May and June 2026
Pages 374-380

  • Receive Date 10 May 2025
  • Accept Date 17 May 2026