Journal of Isfahan Medical School

Journal of Isfahan Medical School

A Comparative Study of the Level of Candida Albicans Infection in Oral Squamous Cell Carcinoma, Oral Dysplastic Lesions, and Normal Mucosa

Document Type : Original Article(s)

Authors
Parya Emamverdizadeh 1
Shirin Fattahi 2
Tannaz Pourlak 3
Shaghayegh Ghadimi 4
Mir Ziya Valiallahzadeh 5
1 Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
2 Associate Professor, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran 0000-0003-4467-6080
3 Department of Oral and Maxillofacial Surgery, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Endodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
5 Dentist, Tabriz, Iran
10.48305/jims.v44.i855.0412
Abstract
Introduction: Candida albicans infection is known as one of the etiological factors of leukoplakia and squamous cell carcinoma of the oral mucosa. The aim of this study was to compare the prevalence of Candida albicans infection in oral mucosa with leukoplakia, squamous cell carcinoma of the oral mucosa compared to normal healthy mucosa.
Materials and Methods: This retrospective study was performed on 60 oral mucosa samples (12 samples related to leukoplakia, 18 samples related to SCC and 30 samples related to normal healthy mucosa). The diagnosis of all the above cases was based on microscopic examination. To identify Candida yeasts, PAS staining was used with a light microscope and magnification of 400. The results were analyzed using Fisher's exact test with a significance level of 0.05.Results: The relative frequency of positive cases of Candida albicans infection in leukoplakia, SCC and normal healthy mucosa samples was reported as 26.67%, 25% and 27.76%, respectively. Statistical analyses showed that there was no significant difference in these respects between the three groups (p = 0.98). Also, the age and gender of the patients did not play a significant role in the detection of Candida yeasts in microscopic samples (p > 0.05).

Highlights

Parya Emamverdizadeh: Google Scholar , PubMed

Tannaz Pourlak: Google Scholar , PubMed

Shirin Fattahi: Google Scholar , PubMed

Shaghayegh Ghadimi: Google Scholar, PubMed

Keywords
Oral squamous cell carcinoma
oral leukoplakia
Candida albicans
Subjects
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Journal of Isfahan Medical School
Volume 44, Issue 855
3rd Week,May
May and June 2026
Pages 412-416

  • Receive Date 16 June 2026
  • Accept Date 30 June 2026