Journal of Isfahan Medical School

Journal of Isfahan Medical School

Investigating the diagnostic effect of Platelet distribution width /Lymphocyte ratio on the prognosis of breast and prostate cancer patients

Document Type : Original Article(s)

Authors
Nahid Moradi Gharibvand 1
Seyed Mohammad Salehi Behbahani 2
Bbagher Pahlavanzadeh 3
Faezeh Alsadat Alboshokeh 4
Batool Hashemibeni 5
1 Department of Anatomical Sciences, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran
2 Assistant Professor of Surgery, School of Medicine, Ayatollah Taleghani Hospital, Shahid Beheshti Hospital, Abadan University of Medical Sciences, Abadan, Iran
3 Assistant Professor of Biostatistics, Department of Biostatistics and Epidemiology, School of Health Research Center for Environmental Contaminants, Abadan University of Medical Sciences, Abadan, Iran
4 Abadan University of Medical Sciences, Abadan, Iran
5 Department of Anatomical Sciences, School of Medicine Dental Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v44.i864.0860
Abstract
Background: Breast and prostate cancer are among the most common malignancies, and their early detection plays an important role in disease control and reducing complications. PDW/Lymphocyte ratio as an inflammatory index may change in patients with cancer, but the results of previous studies in this field have been contradictory. This case-control study was conducted to investigate the diagnostic value of this ratio in patients with breast cancer and compare it with prostate cancer.
Methods: The study was conducted on 111 breast cancer patients, 38 prostate cancer patients, and healthy control groups.
Findings: The results showed that the mean PDW/Lymphocyte ratio in cancer patients was significantly higher than that in healthy individuals. The area under the curve (AUC) was 0.84 in breast cancer and 0.8 in prostate cancer, indicating similar diagnostic power of this index in both diseases.
Conclusion: Overall, the PDW/Lymphocyte ratio can be used as an auxiliary tool in the early diagnosis and follow-up of breast and prostate cancer progression.

Highlights

Nahid Moradi-Gharibvand: Google Scholar

Seyed Mohammad Salehi Behbahani: Google Scholar

Bagher Pahlavanzadeh: Google Scholar

Batool Hashemibeni: Google Scholar

Keywords
Breast cancer
Prostate cancer
Platelet distribution width
Lymphocyte
Subjects
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Journal of Isfahan Medical School
Volume 44, Issue 864
4th Week,July
July and August 2026
Pages 860-867

  • Receive Date 22 December 2025
  • Accept Date 26 July 2026