Journal of Isfahan Medical School

Journal of Isfahan Medical School

Idiopathic Scrotal Calcinosis: A Case Report

Document Type : Case Report

Authors
1 Isfahan Endocrine and Metabolism Research Center (I.E.M.R.C.), Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Urology, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v44.i875.1579
Abstract
Background: Idiopathic scrotal calcinosis is a rare, benign dermatological condition characterized by calcium deposition within the dermis in the absence of systemic or metabolic disorders. Recognition of this entity is important for inclusion in the differential diagnosis of scrotal masses.
Methods: A 51 year old man with no significant medical history presented with a solitary, asymptomatic scrotal nodule that enlarged gradually over 10 years. Physical examination revealed a firm, mobile, non tender lesion confined to the skin. Routine laboratory tests, including serum calcium, phosphorus, complete blood count, and renal function, were within normal limits. The lesion was completely excised.
Findings: Histopathology demonstrated amorphous calcium deposits in the dermis without epithelial lining or active inflammation, consistent with idiopathic scrotal calcinosis. The postoperative course was uneventful, and no recurrence was observed during follow‑up.
Conclusion: Idiopathic scrotal calcinosis should be considered in the differential diagnosis of chronic, asymptomatic scrotal nodules in patients with normal laboratory findings. Complete surgical excision is both diagnostic and therapeutic, with a low recurrence rate.

Highlights

Farid Rajaee Rizi: Google Scholar

Keywords
Subjects

1.     Ye D, Ma X, Yang X. Scrotal calcinosis: a case report and literature review. Am J Clin Exp Urol 2022; 10(3): 194-8.
2.     Gholipour F, Gharakhani D, Hajian MR. Large pyogenic granuloma on the scrotum; a case report. J Nephropathol 2023; x(x): e21420.
3.     Priyadarshee AA, Patnaik S, Baikuntha N, Mahapatra L, Ranjan R. Idiopathic Scrotal Calcinosis: Case Report & Surgical Management of a Rare Condition. Asian J Res Surg 2025; 8(1): 93–8.
4.     Yang X, Tian T, Wang Q. Idiopathic scrotal calcinosis: Case report and literature review. Int J Surg Case Rep 2025; 126: 110770.
5.     Hombal P, Gudadappanavar A. Exploring a rare case of Idiopathic Scrotal Calcinosis: A case report. Ann Afr Surg 2025; 22(2): 66–70.
6.     Killedar MM, Shivani AA, Shinde U. Idiopathic Scrotal Calcinosis. Indian J Surg 2016; 78(4): 329–30.
7.     Khallouk A, Yazami OE, Mellas S, Tazi MF, El Fassi J, Farih MH. Idiopathic Scrotal Calcinosis: A Non-Elucidated Pathogenesis and Its Surgical Treatment. Rev Urol 2011; 13(2): 95–7.
8.     Pompeo A, Molina WR, Pohlman GD, Sehrt D, Kim FJ. Idiopathic scrotal calcinosis: A rare entity and a review of the literature. Can Urol Assoc J 2013; 7(5–6): E439–41.
9.     Scrotal calcinosis: is it idiopathic? - Urology. [cited 2025 Aug 15]. Available from: https://www.goldjournal.net/article/S0090-4295(00)01007-4/abstract
10.  Idiopathic Scrotal Calcinosis (ISC): A Familial Case Series of Two Cases | Cureus. [cited 2025 Sept 7]. Available from: https://www.cureus.com/articles/331587-idiopathic-scrotal-calcinosis-isc-a-familial-case-series-of-two-cases#!/
11.  Khallouk A, Yazami OE, Mellas S, Tazi MF, el Fassi J, Farih MH. Idiopathic Scrotal Calcinosis: A Non-Elucidated Pathogenesis and Its Surgical Treatment. Rev Urol 2011; 13(2): 95–7.
12.  Song DH, Lee KH, Kang WH. Idiopathic calcinosis of the scrotum: Histopathologic observations of fifty-one nodules. J Am Acad Dermatol 1988; 19(6): 1095–101.
13.  Pompeo A, Molina WR, Pohlman GD, Sehrt D, Kim FJ. Idiopathic scrotal calcinosis: A rare entity and a review of the literature. Can Urol Assoc J 2013;7(5–6): E439–41.
14.  Pompeo A, Molina WR, Pohlman GD, Sehrt D, Kim FJ. Idiopathic scrotal calcinosis: A rare entity and a review of the literature. | Canadian Urological Can Urol Assoc J 2013; 7(5-6): E439–E441.
Volume 44, Issue 875
2nd Week,October
September and October 2026
Pages 1579-1583

  • Receive Date 16 August 2025
  • Accept Date 11 October 2026