Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of 12 Weeks of Concurrent Training (Aerobic and Strength) on the Levels of miR-155 and C-reactive Protein in Obese Middle-Aged Men

Document Type : Original Article (s)

Authors
Amir Shakib 1
Ramin Amirsasan 2
Vahid Sari-Sarraf 2
Javad Vakili 2
1 PhD Student in Exercise Physiology, School of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran
2 Associate Professor, Department of Exercise Physiology, School of Physical Education and Sport Sciences, University of Tabriz, Tabriz ,Iran
10.48305/jims.v40.i694.0908
Abstract
Background: Some micro RNAs (miRNA) are secreted by adipose tissue and play a role in intercellular communication and are considered as a valuable target point in order to control obesity and its consequences. The aim of the present study is to determine the effect of two concurrent aerobic and strength training methods on the levels of miR-155 and C-reactive protein (CRP) in obese middle-aged men.
Methods: Thirty middle-aged men with an average age of 44.57 ± 3.54 years and weight 103.79 ± 8.46 kg, randomly and based on fat percentage, aerobic capacity (V̇O2max) and one repetition maximum (1-RM) were assigned to three groups: 1) concurrent aerobic and strength training in one day (CAST1), 2) concurrent aerobic and strength training on separate days (CAST2) and 3) control group. Blood samples were collected from the subjects 48 hours before and after 12 weeks of concurrent training, in order to analyse of miR-155, CRP and glucose indices. One-way ANOVA with repeated measures and Bonferroni's post hoc test were used to analyze the data.
Findings: After 12 weeks of training, CAST1 group experienced a significant decrease in miR-155, CRP and glucose indices compared to the control group. Also, in the CAST2 group, miR-155, CRP and glucose indices were significantly decreased compared to the control group.
Conclusion: It seems that both CAST training methods reduce obesity-related inflammation by affecting
miR-155, and middle-aged men may be able to use both training methods to prevent metabolic diseases.
Keywords
Strength training
Obesity
miR-155
C-reactive protein
Glucose
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Journal of Isfahan Medical School
Volume 40, Issue 694
2nd Week, January
January and February 2023
Pages 908-916

  • Receive Date 26 July 1401
  • Accept Date 30 August 1401