نوع مقاله : مقاله های پژوهشی
1 دانشیار، مرکز تحقیقات بیهوشی و مراقبتهای ویژه، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
2 دانشجوی پزشکی، دانشکدهی پزشکی و کمیتهی تحقیقات دانشجویی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
3 استاد، گروه بیهوشی و مراقبتهای ویژه، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
عنوان مقاله [English]
Background: Etomidate has been used to induce anesthesia with minimum changes in hemodynamic profile in many surgeries. Nevertheless, its infusion for sedation during cataract surgery has been less evaluated. Methods: In a double-blind clinical trial study, 64 patients candidate for cataract surgery under sedation were randomly assigned to receive eitheretomidate-fentanyl (E/F) or ketamine-midazolam-fentanyl (K/M/F) combinations. Systolic and diastolic blood pressures, heart rate, oxygen saturation (SaO2), nausea and vomiting, movement frequency, sedation score, recovery duration, and patients' and surgeon's satisfaction were recorded during the surgeries.Findings: No statistically significant differences were observed in basic systolic and diastolic blood pressures and heart rate between the groups. But, mean systolic and diastolic blood pressures were significantly higher in K/M/F group during and after the surgery (P < 0.050). Systolic and diastolic blood pressures and heart rate did not have significant difference in E/F group (P > 0.050) during surgery but there was significant difference in K/M/F group (P < 0.050). SaO2 in recovery was significantly higher in E/F group (P < 0.001). Incidence of nausea, vomiting and movement episodes, sedation score, and patients' and surgeon's satisfaction were the same in both groups. Recovery duration was significantly less in E/F group (P < 0.001).Conclusion: Combination of etomidate and fentanyl for sedation could be as efficient and safe as ketamine, midazolam, and fentanyl combination in cataract surgery, with less hemodynamic profile changes and recovery time.