Journal of Isfahan Medical School

Journal of Isfahan Medical School

Effect of Exposure to Chronic Heterogeneous Sequential Stress during Prenatal on Formalin-Induced Nociceptive Behaviour in Adult Offspring in Rats

Document Type : Original Article (s)

Authors
Farzad Rajaei 1
Elaheh Erami 2
Hassan Azhdari-Zarmehri 3
1 Professor, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
2 Instructor, Department of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
3 Assistant Professor, Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
Abstract
Background: There are different kinds of stress on mothers during prenatal period. The present study investigated the effects of exposure to chronic heterogeneous sequential stress during prenatal period on formalin-induced nociceptive behavior in adult offspring.Methods: In the present study, animals were divided in stressed and non-stressed groups and their offspring divided in male and female groups. Heterogeneous sequential stress including food deprivation, water deprivation, restraint, restraint at room temperature, restraint at 4◦C, forced swimming and social isolation were applied during days 9 to 19 of gestation. Formalin test as chemical model and hot-plate as thermal pain model were used in rats.Findings: Chronic heterogeneous sequential stress increased the nociceptive behaviors in male rats in first part and in female rats in second part of phase 2 of formalin test compared with controls.Conclusion: The result of this study showed that chronic heterogeneous sequential stress in rats increased the nociceptive behaviours in second phase of formalin test in a gender-dependent order; which suggested chronic heterogeneous sequential stress may be useful in evaluating the basic mechanism of exposure to chronic heterogeneous sequential stress during prenatal period on in adult offspring.
Keywords
Chronic heterogeneous stress
Prenatal
Pain
Formalin test
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Journal of Isfahan Medical School
Volume 31, Issue 256 - Serial Number 256
September and October 2013
Pages 1640-1648

  • Receive Date 18 December 2012
  • Accept Date 06 April 2022