نوع مقاله : مقاله های پژوهشی
1 دانشجوی کارشناسی ارشد، گروه میکروبشناسی، دانشکدهی پزشکی و کمیتهی تحقیقات دانشجویی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
2 دانشیار، گروه میکروبشناسی، دانشکدهی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
عنوان مقاله [English]
Background: Acinetobacter baumannii is one of the most important pathogen in hospital acquired infections, especially in intensive care units (ICUs). This opportunistic pathogen can be easily isolated from water, soil, and hospital facilities. Acinetobacter baumannii, as a nosocomial opportunistic pathogen, is resistant to wide range of antibiotics. The aim of this study was to determine the frequency and resistance patterns of Acinetobacter baumannii isolated from intensive care units of Isfahan Hospitals, Iran.Methods: During one year period (2012-2013), 350 specimens were collected from intensive care units of Isfahan hospitals. The specimens were characterized as Acinetobacter baumannii via conventional phenotypic and biochemical tests. The isolates were confirmed using polymerase chain reaction (PCR) for OXA_51-like gene. Susceptibility of isolates was determined via standard disk diffusion method according to CLSI (Clinical and Laboratory Standards Institute).Findings: From 350 specimens, 43 isolates was Acinetobacter baumannii. 53.5% of isolates were resistant to amikacin, 83.7% to tetracyclin, 86.0% to ceftazidime, 90.7% to trimetoprim sulfametoxazol, 93.0% to imipenem, cefepime, meropenem, and ampicillin-sulbactam. All isolates were resistant to ciprofloxacin. Our findings showed that all of Acinetobacter baumannii, isolated from the intensive care units of Isfahan hospitals were multi-drug resistance (MDR).Conclusion: This study showed a high resistant of Acinetobacter baumannii to a wide range of antimicrobial agent. It is necessary to adopt appropriate strategies to control the spread of the bacteria in care unit centers and wards.