تأثیر دیابت مادری بر تکامل سیستم عصبی مرکزی

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی دکتری، گروه علوم تشریح و بیولوژی مولکولی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 استاد، گروه علوم تشریح و بیولوژی مولکولی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 استادیار، گروه علوم تشریح، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران

چکیده

دیابت حاملگی، یکی از شایع‌ترین و مهم‌ترین اختلالات متابولیک است و می‌تواند باعث چندین ناهنجاری جنینی شود. افزایش قند خون در مادر، می‌تواند اثرات تراتوژنیک بر تکامل سیستم اعصاب مرکزی جنین داشته باشد. شواهد متعددی مشخص کرده است که بچه‌های متولد شده از مادران مبتلا به دیابت، اختلال در رفتار و عملکردهای هوشی را نشان می‌دهند. تشکیلات هیپوکامپ، یکی از نواحی حساس به گلوکز و ناحیه‌ی اصلی در تشکیل و تداوم حافظه‌ی درازمدت است. نوروژنز نیز در هیپوکامپ زمینه‌ی اصلی برای پلاستیسیتی نورونی بوده و با تشکیل حافظه و عملکردهای شناختی در ارتباط است. در این مقاله‌ی مروری، به بررسی اثرات دیابت بر سیستم عصبی در دوره‌ی بارداری پرداخته می‌شود.

کلیدواژه‌ها

عنوان مقاله [English]

Effect of Maternal Diabetes on Developing of Central Nervous System

نویسندگان [English]

  • Akram Sadeghi 1
  • Shahnaz Razavi 2
  • Javad Hami 3
  • Ebrahim Esfandiary 2
1 PhD Student, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Professor, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Assistant Professor, Department of Anatomical Sciences, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
چکیده [English]

Diabetes in pregnancy is the most common and the most important metabolic condition, since it can result in several fetal malformations. Maternal hyperglycemia may have teratogenic effect for developing of fetal central nervous system (CNS). Several lines of evidence indicate that the children born to diabetic mothers, exhibit disturbances in behavioral and intellectual functioning. The hippocampus subserves important behavioral and physiological functions such as memory consolidation, and is a brain structure particularly vulnerable to changes in glucose concentration. Hippocampal neurogenesis might underlie particular aspects of neuronal plasticity and might play an important role for the memory and cognitive functions. We reviewed the current understanding of the effect of diabetes on developing of central nervous system during the pregnancy.

کلیدواژه‌ها [English]

  • Maternal diabetes
  • Neurogenesis
  • Hippocampus
  • Rat neonate

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مجله دانشکده پزشکی اصفهان
دوره 33، شماره 335 - شماره پیاپی 335
خرداد و تیر 1394
صفحه 755-769

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  • تاریخ دریافت: 18 مرداد 1393
  • تاریخ بازنگری: 05 اردیبهشت 1403
  • تاریخ پذیرش: 17 فروردین 1401

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