نوع مقاله : مقاله های پژوهشی
1 کارشناس ارشد، گروه فیزیولوژی، پردیس علوم و تحقیقات زنجان، دانشگاه آزاد اسلامی، زنجان، ایران
2 دانشیار، مرکز تحقیقات بیولوژی، دانشگاه آزاد اسلامی، واحد زنجان، زنجان، ایران
3 دانشیار، گروه فیزیولوژی، دانشکدهی علوم زیستی، دانشگاه شهید بهشتی، تهران، ایران
عنوان مقاله [English]
Background: Brain stroke is still considered to be a big problem for the public health, and is among the four main reasons for death in most of the countries. Common purslane (Portulaca oleracea) is a medically discovered plant investigated in several studies as an adjuvant or replacement treatment and for different diseases. The present study aimed to examine the relationship between common purslane oil consumption and reduction of brain stroke rate in rats. Methods: 35 Wistar male rats weighing 25-300 g were divided into five groups of test (3), control (1), and Sham (1). Test groups received three doses of the aforesaid oil (0.25, 0.50, and 0.75 mg per kg body weight) and the control group received distilled water by gavage. After 30 days gavage, brain stroke surgery was performed on the rats. 24 hours later, animals were checked concerning neurological violations and then, the brain was removed under deep anesthesia and the volume of brain stroke was measured through staining by means of triphenyltetrazolium chloride.Findings: Total volume of brain stroke (mm3) in doses of 0.50 and 0.75 mg per kg body weight indicated a meaningful difference in comparison to the control group. In addition, median score of neurological violations was significantly reduced through Portulaca oleracea oil consumption in the doses of 0.5 and 0.75 mg per kg body weight, compared to the control group.Conclusion: According to the results, common purslane oil can reduce the amount of body tissue damages caused by brain stroke and finally, could lead to a kind of neurological protection.