بررسی تأثیر تغییرات ضخامت بافت نرم بر نتایج تراکم معدنی استخوان به روش Dual-Energy X-Ray Absorptiometry (DXA)

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دانشیار، مرکز تحقیقات بیوسنسور و گروه فیزیک پزشکی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان و مرکز تشخیص پوکی استخوان اصفهان، اصفهان، ایران

2 دانشجوی کارشناسی ارشد، گروه فیزیک پزشکی، دانشکده پزشکی و کمیته‌ی تحقیقات دانشجویی، دانشگاه علوم پزشکی اصفهان

3 مرکز تشخیص پوکی استخوان اصفهان، اصفهان، ایران

4 دانشیار، گروه فیزیک پزشکی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: ارزیابی تراکم ماده‌ی معدنی استخوان (BMD یا Bone mineral density) با استفاده از روش جذب اشعه‌ی ایکس با انرژی دوگانه (DXA یا Dual-energy X-ray absorptiometry) نقش مهمی در تشخیص و روند پاسخ به درمان پوکی استخوان ایفا می‌کند. تغییرات ضخامت بافت نرم، می‌تواند موجب خطاهای احتمالی در مقادیر استخوانی روش DXA گردد. هدف از این مطالعه، بررسی تأثیر بافت نرم بر تراکم استخوانی به روش DXA می‌باشد.روش‌ها: با طراحی فانتوم ستون فقرات کمری که در آن از مواد معادل استخوان (آلومینیوم) و بافت نرم (پلکسی گلاس) استفاده شد، افراد با وضعیت‌های متفاوت استخوانی (طبیعی، استئوپنی، استئوپروز) و ضخامت‌های شکمی گوناگون شبیه‌سازی شدند. تعداد 45 اسکن DXA با استفاده از دستگاه Norland XR-46 تهیه گردید. مقادیر BMD، محتوای ماده‌ی معدنی استخوان (BMC یا Bone mineral content) و ناحیه‌ی استخوانی (BA یا Bone area) از طریق ضریب همبستگی Pearson و آنالیز رگرسیون با استفاده از نرم‌افزار SPSS مورد تجزیه و تحلیل قرار گرفت.یافته‌ها: آزمون همبستگی Pearson نشان داد که تغییرات ضخامت بافت نرم، با هیچ یک از کمیت‌های BMD،BMC و BA رابطه‌ی آماری معنی‌داری ندارد (050/0 < P). با استفاده از رگرسیون ناپارامتریک، مشخص شد که تغییرات بافت نرم بر روی کمیت‌های BMD و BMC تأثیر دارد (050/0 > P)، اما بر روی کمیت BA هیچ تاثیر معنی‌داری ندارد (050/0 < P).نتیجه‌گیری: تغییرات ضخامت بافت نرم، تأثیر مستقیم اندکی (کمتر از 1 درصد) بر تراکم استخوانی داشت. بنا بر این، میزان خطای ناشی از تغییرات بافت نرم در سیستم DXA مورد بررسی در این مطالعه، قابل صرف‌نظر است.

کلیدواژه‌ها


عنوان مقاله [English]

Assessing the Effect of in-vitro Soft Tissue Thickness on Bone Mineral Density Using Dual-Energy X-ray Absorptiometry

نویسندگان [English]

  • Mohammad Reza Salamat 1
  • Afsaneh Keshavarz 2
  • Amir Hossein Salamat 3
  • Ahmad Shanei 4
1 Associate Professor, Biosensor Research Center AND Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences AND Isfahan Osteoporosis Diagnosis Center, Isfahan, Iran
2 MSc Student, Department of Medical Physics, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
3 Isfahan Osteoporosis Diagnosis Center, Isfahan, Iran
4 Associate Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Bone mineral density (BMD) assessment by using dual-energy X-ray absorptiometry (DXA) plays an important role in diagnosis and treatment of osteoporosis. Variation in soft tissue thickness may cause probability errors in DXA bone values. The aim of this study was to assess the effect of soft tissue thickness on bone mineral.Methods: A spine phantom consisting of bone and soft tissue equivalents (Aluminum and Perspex respectively) was made to simulate different status of bone (normal, osteopenia and osteoporosis) and abdominal thicknesses. BMD measurements were performed by DXA using a Norland XR-46 on 45 patients. The statistical analysis for determining the BMD, bone mineral content (BMC), bone area (BA) measurements was done using SPSS software.Findings: According to Pearson correlation test, variation of soft tissue thickness had no statistically significant relation on BMD, BMC and BA (P > 0.05). But non-parametric regression determined soft tissue thickness had some effect on BMD and BMC (P < 0.05), but no statistically effect on BA (P > 0.05).Conclusion: Variation of soft tissue thickness had no considerable effect (less than1%) on bone mineral results, so errors arising from soft tissue thickness in DXA are negligible

کلیدواژه‌ها [English]

  • Soft tissue
  • Dual-energy X-ray absorptiometry (DXA)
  • Bone density
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