تأثیر 12 هفته تمرین هوازی با و بدون محدودیت کالری بر شاخص‌های متابولیک و سطوح پلاسمایی ویسفاتین در زنان یائسه‌ی سالمند

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 کارشناسی ارشد، گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی، واحد نجف آباد، نجف آباد، ایران

2 استاد، مرکز تحقیقات طب ورزشی، دانشگاه آزاد اسلامی، واحد نجف‌آباد، نجف‌آباد، ایران

چکیده

چکیدهمقدمه: مطالعات قبلی توصیه کرده‌اند که ترکیب محدودیت کالری و تمرین ورزشی هوازی، نسبت به تمرین هوازی به تنهایی، برای بهبود شاخص‌های متابولیک و سطوح ویسفاتین زنان سالمند چاق بهتر است. هدف از انجام این مطالعه، بررسی اثر 12 هفته تمرین هوازی با و بدون محدودیت کالری بر سطوح پلاسمایی ویسفاتین و شاخص‌های متابولیک در زنان یائسه‌ی سالمند بود.روش‌ها: 60 نفر از زنان یائسه‌ی سالمند با سن 80-60 سال، به طور تصادفی در یکی از 3 گروه 20 نفری تمرین هوازی به همراه رژیم غذایی، تمرین هوازی و رژیم غذایی به تنهایی قرار گرفتند. افراد در گروه رژیم غذایی و ورزش، علاوه بر داشتن برنامه‌ی رژیم غذایی، یک برنامه‌ی تمرین هوازی شامل 45-25 دقیقه، 3 بار در هفته با شدت 75-50 درصد حداکثر ضربان قلب را به مدت 12 هفته اجرا کردند. نشانگرهای متابولیک و سطوح ویسفاتین پلاسمایی در حالت پایه و پایان مطالعه اندازه‌گیری شد.یافته‌ها: پس از 12 هفته مداخله، کاهش قابل توجهی در کلسترول، تری‌گلیسرید، لیپوپروتئین کم‌چگال، گلوکز، انسولین، مقاومت انسولین و سطوح ویسفاتین پلاسما در هر سه گروه و افزایش معنی‌داری در لیپوپروتئین پرچگال در دو گروه ترکیبی و ورزش به تنهایی مشاهده شد (05/0 > P). تغییرات بین گروهی تفاوت معنی‌داری در کلسترول تام، لیپوپروتئین کم‌چگال و تری‌گلیسیرید زنان یائسه‌ی سالمند پس از 12 هفته مداخله را نشان داد (05/0 > P).نتیجه‌گیری: تمرین هوازی همراه با محدودیت کالری متوسط، موجب کاهش قابل توجه در نشانگرهای متابولیک و سطوح ویسفاتین پلاسما در زنان یائسه‌ی سالمند می‌شود.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of 12 Weeks of Aerobic Exercise with and without Caloric Restriction on Visfatin Plasma Levels and Metabolic Indicators in Elderly Postmenopausal Women

نویسندگان [English]

  • Masoumeh Mohammadi 1
  • Mehdi Kargarfard 2
1 Department of Physical Education and Sport Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran
2 Professor, Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran
چکیده [English]

AbstractBackground: Previous findings have suggested that combined caloric restriction and aerobic exercise training is better than aerobic exercise alone for improving metabolic indicators and visfatin levels in obese old women. The aim of this study was to investigate the effect of 12 weeks of aerobic exercise with and without caloric restriction on body composition and visfatin plasma levels in elderly postmenopausal women.Methods: Sixteen elder postmenopausal women aged 60-80 years were randomized in one of the 3 groups of 20 subjects, diet plus aerobic exercise, aerobic exercise and diet only. In addition to the dietary program, subjects in diet plus aerobic exercise group performed an exercise training program of 25-45 minutes, 3 times a week with 50-70 percent of maximal heart rate for 12 weeks. Metabolic indicators including triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (HDL-C), high-density lipoprotein cholesterol (LDL-C), glucose, insulin, insulin resistance, and plasma levels visfatin were measured at baseline and at the end of the study. Data were analyzed using repeated measures analysis of variance (ANOVA) analysis.Findings: After 12 weeks of the intervention, significant decreases in TG, TC, LDL-C, glucose, insulin, insulin resistance, and visfatin plasma levels and increases in HDL-C were seen in the groups (P < 0.05 for all). However, there were significant differences in TC, TG and LDL-C between the groups after 12 weeks of the intervention (P < 0.05).Conclusion: Exercise training with moderate caloric restriction diet induced a significant reduction of metabolic indicators and visfatin plasma levels in older postmenopausal women.

کلیدواژه‌ها [English]

  • Aerobic training
  • Diet
  • Visfatin
  • Elder postmenopausal women
  1. Razavi M, Aftekhar Ardabili H, Seyed Nozadi M, Parizad SM, Hatami H. Public health text book. Tehran, Iran: Arjomand Publications; 2008. [In Persian].
  2. Gordon T, Kannel WB, Hjortland MC, McNamara PM. Menopause and coronary heart disease. The Framingham Study. Ann Intern Med 1978; 89(2): 157-61.
  3. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37(12): 1595-607.
  4. Day C. Metabolic syndrome, or what you will: definitions and epidemiology. Diab Vasc Dis Res 2007; 4(1): 32-8.
  5. Munakata M, Honma H, Akasi M, Araki T, Kawamura T, Kubota M, et al. Japanese study to organize proper lifestyle modifications for metabolic syndrome (J-STOP-MetS): design and method. Vasc Health Risk Manag 2008; 4(2): 415-20.
  6. Caterson ID. Medical management of obesity and its complications. Ann Acad Med Singapore 2009; 38(1): 22-7.
  7. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307(5708): 426-30.
  8. Lee KJ, Shin YA, Lee KY, Jun TW, Song W. Aerobic exercise training-induced decrease in plasma visfatin and insulin resistance in obese female adolescents. Int J Sport Nutr Exerc Metab 2010; 20(4): 275-81.
  9. Haider DG, Pleiner J, Francesconi M, Wiesinger GF, Muller M, Wolzt M. Exercise training lowers plasma visfatin concentrations in patients with type 1 diabetes. J Clin Endocrinol Metab 2006; 91(11): 4702-4.
  10. Brema I, Hatunic M, Finucane F, Burns N, Nolan JJ, Haider D, et al. Plasma visfatin is reduced after aerobic exercise in early onset type 2 diabetes mellitus. Diabetes Obes Metab 2008; 10(7): 600-2.
  11. Bagheri N. Effects of aerobic exercise training on plasma visfatin levels and insulin resistance in obese adolescents [Thesis]; Shahrekord, Iran: Shahrekord University; 2011. [In Persian].
  12. King MB, Whipple RH, Gruman CA, Judge JO, Schmidt JA, Wolfson LI. The performance enhancement project: improving physical performance in older persons. Arch Phys Med Rehabil 2002; 83(8): 1060-9.
  13. Ogburn T, Voss C, Espey E. Barriers to women's health: why is it so hard for women to stay healthy? Med Clin North Am 2008; 92(5): 993-1009, ix.
  14. Haus JM, Solomon TP, Marchetti CM, O'Leary VB, Brooks LM, Gonzalez F, et al. Decreased visfatin after exercise training correlates with improved glucose tolerance. Med Sci Sports Exerc 2009; 41(6): 1255-60.
  15. Seo DI, So WY, Ha S, Yoo EJ, Kim D, Singh H, et al. Effects of 12 weeks of combined exercise training on visfatin and metabolic syndrome factors in obese middle-aged women. J Sports Sci Med 2011; 10(1): 222-6.
  16. Mckenzie JA. The influence of visfatin and visfatin gene polymorphisms on glucose and obesity-related variables and their responses to aerobic exercise training. Kinesiology 2010; 303: 314-28.
  17. Earl R, Borr ST. Guidelines for dietary planning. In: Mahan LK, Escott-Stump S, Editors. Krause's Food, Nutrition, & Diet Therapy. 11th ed. Philadelphia, PA: Saunders; 2004. p. 364-412.
  18. Mahan LK, Escott-Stump S, Raymond JL, Krause MV. Krause's food & the nutrition care process. Philadelphia, PA: Elsevier Health Sciences; 2012.
  19. Ahmadizad S, Rahmani H, Bassami MR, Tahmasebi W. Relationship between resting plasma visfatin levels and its changes in response to acute endurance exercise with aerobic fitness and body composition in healthy men. Sport Physiology 2012; 4(15): 27-38. [In Persian].
  20. Berndt J, Kloting N, Kralisch S, Kovacs P, Fasshauer M, Schon MR, et al. Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes 2005; 54(10): 2911-6.
  21. Chen MP, Chung FM, Chang DM, Tsai JC, Huang HF, Shin SJ, et al. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 2006; 91(1): 295-9.
  22. Koskova I, Petrasek R, Vondra K, Duskova M, Starka L. Metabolic profile and sex hormone binding globulin (SHBG) in different reproductive phases of Czech women and their relations to weight, body composition and fat distribution. Physiol Res 2009; 58(3): 393-402.
  23. Farshidfar GR, Yousfi H, Vakili M, Asadi Noughabi F. The effect of ramadan fasting on hemoglobin, hematocrit and blood biochemical parameters. J Res Health Sci 2006; 6(2): 21-7. [In Persian].
  24. Redman LM, Heilbronn LK, Martin CK, Alfonso A, Smith SR, Ravussin E. Effect of calorie restriction with or without exercise on body composition and fat distribution. J Clin Endocrinol Metab 2007; 92(3): 865-72.
  25. Talanian JL, Galloway SD, Heigenhauser GJ, Bonen A, Spriet LL. Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. J Appl Physiol (1985) 2007; 102(4): 1439-47.
  26. Ben Ounis O, Elloumi M, Ben Chiekh I, Zbidi A, Amri M, Lac G, et al. Effects of two-month physical-endurance and diet-restriction programmes on lipid profiles and insulin resistance in obese adolescent boys. Diabetes Metab 2008; 34(6 Pt 1): 595-600.
  27. Toruner F, Altinova AE, Bukan N, Arslan E, Akbay E, Ersoy R, et al. Plasma visfatin concentrations in subjects with type 1 diabetes mellitus. Horm Res 2009; 72(1): 33-7.
  28. de Souza e Silva M, de Souza Rabelo A, Vale R, Ferrao M, Gonçalves L, de Sa Rego Forte M, et al. Effects of two kinds of aerobic training on body fat content and serum lipid profile in cadets. Biomedical Human Kinetics 2009; 1(1): 72-5.
  29. El-Mesallamy HO, Kassem DH, El-Demerdash E, Amin AI. Vaspin and visfatin/Nampt are interesting interrelated adipokines playing a role in the pathogenesis of type 2 diabetes mellitus. Metabolism 2011; 60(1): 63-70.
  30. Jürimäe J, Rämson R, Mäestu J, Purge P, Jürimäe T, Arciero PJ, et al. Plasma visfatin and ghrelin response to prolonged sculling in competitive male rowers. Med Sci Sports Exerc 2009; 41(1): 137-43.
  31. Costford SR1, Bajpeyi S, Pasarica M, Albarado DC, Thomas SC, Xie H, et al. Skeletal muscle NAMPT is induced by exercise in humans. Am J Physiol Endocrinol Metab 2010; 298(1): E117-26.