بررسی ارتباط دریافت‌های غذایی و ترکیب بدن با ضخامت اینتیمای شریان کاروتید در بیماران با حمله‌ی ایسکمیک گذرا

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد، مرکز تحقیقات امنیت غذایی و گروه تغذیه‌‌ی علوم جامعه، کمیته‌ی‌ تحقیقات دانشجویی، دانشکده‌ی‌ تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 استادیار، مرکز تحقیقات علوم اعصاب و گروه داخلی اعصاب، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 مربی، گروه اپیدمیولوژی و آمار زیستی، دانشکده‌ی بهداشت، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

4 استادیار، مرکز تحقیقات امنیت غذایی و گروه تغذیه‌ی‌ علوم جامعه، دانشکده‌ی تغذیه و علوم غذایی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: مطالعات مبتنی بر جمعیت در بسیاری از کشورها ثابت کرده‌اند که ضخامت اینتیمای شریان کاروتید (Intima-media thickness یا IMT) با بروز سکته‌ی مغزی ارتباط مثبتی دارد. در برخی مطالعات پیشنهاد شده است که بسیاری از غذاها یا ترکیب بدن روی خطر بروز سکته‌ی مغزی تأثیر می‌گذارند. با این حال، تحقیقات پیشین ارتباط هم‌زمان بین رژیم غذایی و ترکیب بدن با ضخامت اینتیمای شریان کاروتید را بررسی نکرده‌اند. مطالعه‌ی حاضر با هدف بررسی ارتباط بین دریافت‌های غذایی و ترکیب بدن با ضخامت اینتیمای شریان کاروتید در بیماران با حمله‌ی ایسکمیک گذرا (Transient ischemic attack یا TIA) انجام شد.روش‌ها: در این مطالعه‌ی مقطعی، 100 نفر از افراد 35 تا 80 ساله‌ی مبتلا به حمله‌ی ایسکمیک گذرا با توجه به معیارهای ورود و خروج انتخاب شدند. دریافت‌های غذایی، ضخامت اینتیمای شریان کاروتید و ترکیب بدن در تمام افراد ارزیابی گردید. جهت بررسی ارتباط بین ضخامت اینتیمای شریان کاروتید و سایر متغیرها، ضریب همبستگی Pearson مورد استفاده قرار گرفت.یافته‌ها: ضخامت اینتیمای شریان کاروتید با دریافت اسید لینولئیک و ویتامین E ارتباط معکوس معنی‌داری داشت، اما رابطه‌ی معنی‌داری بین ضخامت اینتیمای شریان کاروتید با دریافت سایر درشت مغذی‌ها و ریزمغذی‌ها مشاهده نشد. از سوی دیگر، ارتباط ضخامت اینتیمای شریان کاروتید با توده‌ی چربی بدن (Body fat mass یا BFM)، میزان چربی احشایی، دور شکم، مواد معدنی بدن و پروتئین بدن معنی‌دار بود.نتیجه‌گیری: نتایج پژوهش حاضر نشان داد که ممکن است بسیاری از دریافت‌های غذایی بر روی ضخامت اینتیمای شریان کاروتید تأثیری نداشته باشد، اما توده‌ی چربی بدن و شاخص‌های چاقی شکمی ارتباط بیشتری با ضخامت اینتیمای شریان کاروتید دارند

کلیدواژه‌ها

عنوان مقاله [English]

Relationship between Dietary Intake and Body Composition with Carotid Intima-Media Thickness in Patients with Transient Ischemic Attack

نویسندگان [English]

  • Asefeh Kiani 1
  • Fariborz Khorvash 2
  • Akbar Hasanzadeh 3
  • Gholamreza Askari 4
1 MSc Student, Food Security Research Center AND Department of Community Nutrition, Student Research Committee, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Isfahan Neuroscience Research Center AND Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Lecturer, Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
4 Assistant Professor, Food Security Research Center AND Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Population-based studies in many countries have shown that carotid intima-media thickness (IMT) has a positive relationship with stroke. Some studies have suggested that many of the foods or body composition have effect on the risk of stroke. However, previous studies have not investigated the relationship between dietary intake and body composition with carotid intima-media thickness. This study aimed to evaluate the relationship between dietary intakes and body compositions with carotid intima-media thickness in patients with transient ischemic attack (TIA).Methods: In this cross-sectional study, 100 patients (35 to 85 years old) with transient ischemic attack, according to the inclusion and exclusion criteria were enrolled. The carotid intima-media thicknes was measured, usual dietary intakes was assessed and body composition was examined for each patient. Pearson’s correlation was used to examine the relationship between the carotid intima-media thickness and other variables.Findings: The carotid intima-media thickness had a significant negative correlation with intake of linoleic acid and vitamin E, but there was not any relationship with other macronutrients and micronutrients. On the other hand, carotid intima-media thickness was significantly associated with body fat mass, visceral fat area, abdominal circumference, mineral and protein of body.Conclusion: These data indicated that many of dietary intakes may not have any effect on carotid intima-media thickness but body fat and abdominal obesity indices may be associated with carotid intima-media thickness.

کلیدواژه‌ها [English]

  • Body composition
  • Carotid intima-media thickness
  • Transient ischemic attack

مراجع

  1. Simmons BB, Cirignano B, Gadegbeku AB. Transient ischemic attack: Part I. Diagnosis and evaluation. Am Fam Physician 2012; 86(6): 521-6.
  2. Dhamoon MS, Sciacca RR, Rundek T, Sacco RL, Elkind MS. Recurrent stroke and cardiac risks after first ischemic stroke: the Northern Manhattan Study. Neurology 2006; 66(5): 641-6.
  3. Sandercock P. Vitamin B supplements for prevention of stroke. Lancet Neurol 2010; 9(9): 842-3.
  4. Touboul PJ, Labreuche J, Vicaut E, Amarenco P. Carotid intima-media thickness, plaques, and Framingham risk score as independent determinants of stroke risk. Stroke 2005; 36(8): 1741-5.
  5. Kawamori R, Yamasaki Y, Matsushima H, Nishizawa H, Nao K, Hougaku H, et al. Prevalence of carotid atherosclerosis in diabetic patients. Ultrasound high-resolution B-mode imaging on carotid arteries. Diabetes Care 1992; 15(10): 1290-4.
  6. Matsumoto K, Sera Y, Nakamura H, Ueki Y, Miyake S. Correlation between common carotid arterial wall thickness and ischemic stroke in patients with type 2 diabetes mellitus. Metabolism 2002; 51(2): 244-7.
  7. Ebrahim S, Papacosta O, Whincup P, Wannamethee G, Walker M, Nicolaides AN, et al. Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: the British Regional Heart Study. Stroke 1999; 30(4): 841-50.
  8. Kitamura A, Iso H, Imano H, Ohira T, Okada T, Sato S, et al. Carotid intima-media thickness and plaque characteristics as a risk factor for stroke in Japanese elderly men. Stroke 2004; 35(12): 2788-94.
  9. Nagai Y, Kitagawa K, Sakaguchi M, Shimizu Y, Hashimoto H, Yamagami H, et al. Significance of earlier carotid atherosclerosis for stroke subtypes. Stroke 2001; 32(8): 1780-5.
  10. Bonithon-Kopp C, Touboul PJ, Berr C, Leroux C, Mainard F, Courbon D, et al. Relation of intima-media thickness to atherosclerotic plaques in carotid arteries. The Vascular Aging (EVA) Study. Arterioscler Thromb Vasc Biol 1996; 16(2): 310-6.
  11. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997; 96(5): 1432-7.
  12. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK, Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999; 340(1): 14-22.
  13. Touboul PJ, Elbaz A, Koller C, Lucas C, Adrai V, Chedru F, et al. Common carotid artery intima-media thickness and brain infarction : the Etude du Profil Genetique de l'Infarctus Cerebral (GENIC) case-control study. The GENIC Investigators. Circulation 2000; 102(3): 313-8.
  14. Kalogeropoulos A, Terzis G, Chrysanthopoulou A, Hahalis G, Siablis D, Alexopoulos D. Risk for transient ischemic attacks is mainly determined by intima-media thickness and carotid plaque echogenicity. Atherosclerosis 2007; 192(1): 190-6.
  15. Hankey GJ, Eikelboom JW, Yi Q, Lees KR, Chen C, Xavier D, et al. Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial. Lancet Neurol 2012; 11(6): 512-20.
  16. Khanna S, Heigel M, Gnyawali S, Sen CK, Rink C. Abstract T MP109: Tocotrienol induces TIMP1 expression and pro-arteriogenic remodeling of cerebrovascular collaterals. Stroke 2014; 45(Suppl 1): ATMP109.
  17. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ 2011; 342: d2040.
  18. Fung TT, Stampfer MJ, Manson JE, Rexrode KM, Willett WC, Hu FB. Prospective study of major dietary patterns and stroke risk in women. Stroke 2004; 35(9): 2014-9.
  19. Mahe G, Ronziere T, Laviolle B, Golfier V, Cochery T, De Bray JM, et al. An unfavorable dietary pattern is associated with symptomatic ischemic stroke and carotid atherosclerosis. J Vasc Surg 2010; 52(1): 62-8.
  20. Strazzullo P, D'Elia L, Kandala NB, Cappuccio FP. Salt intake, stroke, and cardiovascular disease: meta-analysis of prospective studies. BMJ 2009; 339: b4567.
  21. Kernan WN, Ovbiagele B, Black HR, Bravata DM, Chimowitz MI, Ezekowitz MD, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014; 45(7): 2160-236.
  22. Winter Y, Rohrmann S, Linseisen J, Lanczik O, Ringleb PA, Hebebrand J, et al. Contribution of obesity and abdominal fat mass to risk of stroke and transient ischemic attacks. Stroke 2008; 39(12): 3145-51.
  23. van Dijk SC, Enneman AW, Swart KM, van Wijngaarden JP, Ham AC, Brouwer-Brolsma EM, et al. Effects of 2-year vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly on arterial stiffness and cardiovascular outcomes within the B-PROOF trial. J Hypertens 2015; 33(9): 1897-906.
  24. Sala-Vila A, Romero-Mamani ES, Gilabert R, Nunez I, de la Torre R, Corella D, et al. Changes in ultrasound-assessed carotid intima-media thickness and plaque with a Mediterranean diet: a substudy of the PREDIMED trial. Arterioscler Thromb Vasc Biol 2014; 34(2): 439-45.
  25. Agarwal M, Mehta PK, Dwyer JH, Dwyer KM, Shircore AM, Nordstrom CK, et al. Differing relations to early atherosclerosis between vitamin C from supplements vs. food in the Los Angeles Atherosclerosis Study: A prospective cohort study. Open Cardiovasc Med J 2012; 6: 113-21.
  26. Mirmiran P, Esfahani FH, Mehrabi Y, Hedayati M, Azizi F. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public Health Nutr 2010; 13(5): 654-62.
  27. Itkonen ST, Karp HJ, Kemi VE, Kokkonen EM, Saarnio EM, Pekkinen MH, et al. Associations among total and food additive phosphorus intake and carotid intima-media thickness--a cross-sectional study in a middle-aged population in Southern Finland. Nutr J 2013; 12: 94.
  28. Tugasworo D, Pudjonarko D, Latifah L. Correlation of folic intake and internal carotid artery intima-media thickness changes in post ischemic stroke patients. International Journal of Science and Engineering 2015; 8(2): 159-66.
  29. Bemelmans WJ, Lefrandt JD, Feskens EJ, van Haelst PL, Broer J, Meyboom-de JB, et al. Increased alpha-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis. Eur J Clin Nutr 2004; 58(7): 1083-9.
  30. Hino A, Adachi H, Toyomasu K, Yoshida N, Enomoto M, Hiratsuka A, et al. Very long chain N-3 fatty acids intake and carotid atherosclerosis: an epidemiological study evaluated by ultrasonography. Atherosclerosis 2004; 176(1): 145-9.
  31. Ebbesson SO, Roman MJ, Devereux RB, Kaufman D, Fabsitz RR, Maccluer JW, et al. Consumption of omega-3 fatty acids is not associated with a reduction in carotid atherosclerosis: the Genetics of Coronary Artery Disease in Alaska Natives study. Atherosclerosis 2008; 199(2): 346-53.
  32. He K, Liu K, Daviglus ML, Mayer-Davis E, Jenny NS, Jiang R, et al. Intakes of long-chain n-3 polyunsaturated fatty acids and fish in relation to measurements of subclinical atherosclerosis. Am J Clin Nutr 2008; 88(4): 1111-8.
  33. Kritchevsky SB, Shimakawa T, Tell GS, Dennis B, Carpenter M, Eckfeldt JH, et al. Dietary antioxidants and carotid artery wall thickness. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation 1995; 92(8): 2142-50.
  34. Azen SP, Qian D, Mack WJ, Sevanian A, Selzer RH, Liu CR, et al. Effect of supplementary antioxidant vitamin intake on carotid arterial wall intima-media thickness in a controlled clinical trial of cholesterol lowering. Circulation 1996; 94(10): 2369-72.
  35. McQuillan BM, Hung J, Beilby JP, Nidorf M, Thompson PL. Antioxidant vitamins and the risk of carotid atherosclerosis. The Perth Carotid Ultrasound Disease Assessment study (CUDAS). J Am Coll Cardiol 2001; 38(7): 1788-94.
  36. Salonen JT, Nyyssonen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E, et al. Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Intern Med 2000; 248(5): 377-86.
  37. Till U, Rohl P, Jentsch A, Till H, Muller A, Bellstedt K, et al. Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, vitamins B6 and B12. Atherosclerosis 2005; 181(1): 131-5.
  38. Masley SC, Roetzheim R, Masley LV, McNamara T, Schocken DD. Abstract P056: Emerging lifestyle markers predict regression of carotid intima-media thickness scores. Circulation 2015; 131(Suppl 1): AP056.
  39. Yang YJ, Choi BY, Chun BY, Kweon SS, Lee YH, Park PS, et al. Dietary zinc intake is inversely related to subclinical atherosclerosis measured by carotid intima-media thickness. Br J Nutr 2010; 104(8): 1202-11.
  40. de Oliveira Otto MC, Alonso A, Lee DH, Delclos GL, Jenny NS, Jiang R, et al. Dietary micronutrient intakes are associated with markers of inflammation but not with markers of subclinical atherosclerosis. J Nutr 2011; 141(8): 1508-15.
  41. Vergnaud AC, Bertrais S, Zureik M, Galan P, Blacher J, Hercberg S, et al. Dietary iron intake and serum ferritin in relation to 7.5 years structure and function of large arteries in the SUVIMAX cohort. Diabetes Metab 2007; 33(5): 366-71.
  42. Guerrero-Romero F, Rodriguez-Moran M. Hypomagnesemia, oxidative stress, inflammation, and metabolic syndrome. Diabetes Metab Res Rev 2006; 22(6): 471-6.
  43. Guerrero-Romero F, Tamez-Perez HE, Gonzalez-Gonzalez G, Salinas-Martinez AM, Montes-Villarreal J, Trevino-Ortiz JH, et al. Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab 2004; 30(3): 253-8.
  44. Altura BT, Brust M, Bloom S, Barbour RL, Stempak JG, Altura BM. Magnesium dietary intake modulates blood lipid levels and atherogenesis. Proc Natl Acad Sci U S A 1990; 87(5): 1840-4.
  45. Touyz RM. Role of magnesium in the pathogenesis of hypertension. Mol Aspects Med 2003; 24(1-3): 107-36.
  46. Ruan L, Chen W, Srinivasan SR, Xu J, Toprak A, Berenson GS. Relation of serum phosphorus levels to carotid intima-media thickness in asymptomatic young adults (from the Bogalusa Heart Study). Am J Cardiol 2010; 106(6): 793-7.
  47. Vervloet MG, van Ittersum FJ, Buttler RM, Heijboer AC, Blankenstein MA, ter Wee PM. Effects of dietary phosphate and calcium intake on fibroblast growth factor-23. Clin J Am Soc Nephrol 2011; 6(2): 383-9.
  48. Dalal M, Sun K, Cappola AR, Ferrucci L, Crasto C, Fried LP, et al. Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling women. Eur J Endocrinol 2011; 165(5): 797-803.
  49. Gutierrez OM, Wolf M, Taylor EN. Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up study. Clin J Am Soc Nephrol 2011; 6(12): 2871-8.
  50. Schoppet M, Hofbauer LC, Brinskelle-Schmal N, Varennes A, Goudable J, Richard M, et al. Serum level of the phosphaturic factor FGF23 is associated with abdominal aortic calcification in men: the STRAMBO study. J Clin Endocrinol Metab 2012; 97(4): E575-E583.
  51. Kendrick J, Kestenbaum B, Chonchol M. Phosphate and cardiovascular disease. Adv Chronic Kidney Dis 2011; 18(2): 113-9.
  52. Garcia-Ortiz L, Recio-Rodriguez JI, Rodriguez-Sanchez E, Patino-Alonso MC, Agudo-Conde C, Rodriguez-Martin C, et al. Sodium and potassium intake present a J-shaped relationship with arterial stiffness and carotid intima-media thickness. Atherosclerosis 2012; 225(2): 497-503.
مجله دانشکده پزشکی اصفهان
دوره 34، شماره 414 - شماره پیاپی 414
بهمن و اسفند 1395
صفحه 1617-1626

فایل ها

سابقه مقاله

  • تاریخ دریافت: 24 مرداد 1395
  • تاریخ بازنگری: 05 اردیبهشت 1403
  • تاریخ پذیرش: 17 فروردین 1401

هم رسانی

ارجاع به این مقاله

آمار