بررسی زمان بقا و عود بیماران مبتلا به سرطان کولون در مراجعین به مرکز آموزشی- درمانی الزهرای (س) اصفهان در سال‌های 90-1381

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دانشیار، گروه جراحی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 دانشجوی پزشکی، کمیته‌ی تحقیقات دانشجویی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: سرطان کولون در مقایسه با سایر بدخیمی‌ها، شیوع بالایی دارد و از طرفی، این بیماری دارای علایم بسیار شدید و پیش‌آگهی ضعیفی است. از این رو، هدف از انجام مطالعه‌ی حاضر، بررسی زمان بقا و عود بیماران مبتلا به سرطان کولون در طی 10 سال بود.روش‌ها: مطالعه‌ی حاضر، بر روی 100 بیمار انجام گرفت. برای جمع‌آوری اطلاعات مربوط به هر یک از بیماران، از پرونده‌های بیمارستانی آن‌ها استفاده شد. در صورت وجود نقص در پرونده و یا عدم اطلاع از وضعیت فعلی بیمار، از طریق آدرس و یا شماره‌ی تلفن با بیماران تماس گرفته شد و نواقص موجود در پرونده برطرف گردید. جهت تعیین میزان بقا، از روش Kaplan-Meier و برای مقایسه‌ی میزان بقا، از روش Log rank استفاده شد.یافته‌ها: از میان شرکت کنندگان، 64 نفر (64 درصد) مرد و 36 نفر (36 درصد) زن بودند. همچنین، بقای یک ساله برابر 89 درصد و بقای 5 ساله برابر 47 درصد بود. تعداد 54 درصد از مراجعین در قید حیات بودند و میانگین و میانه‌ی زمان بقای بیماران به ترتیب 78/57 و 00/62 ماه (81/4 و 17/5 سال) بود. همچنین، مشخص شد که دریافت شیمی‌درمانی بعد از عمل و عود موضعی، بر روی بقای بیماران تأثیر معنی‌داری دارد (050/0 > P). در عود موضعی، تنها 22 درصد از مراجعین دچار عود شده بودند و جنسیت، مرحله‌ی (Stage) بیماری، متاستاز کبدی، وضعیت فعلی بیمار و درگیری گره‌ی لنفاوی بر روی زمان عود بیماری افراد مبتلا به سرطان کولون مؤثر بود (050/0 > P).نتیجه‌گیری: مرحله‌ی بیماری، شیمی‌درمانی بعد از عمل، عود موضعی و درگیری گره‌ی لنفاوی در میزان بقای بیماران مؤثر است و سبب تغییر میزان بقای بیماران می‌شود. از این رو، با تشخیص زود هنگام بیماران و ترکیب چندین روش درمانی، می‌توان میزان بقای بیماران را افزایش داد.

کلیدواژه‌ها

عنوان مقاله [English]

Survival and Recurrence Time among Patients with Colon Cancer Reffered to Alzahra Hospital, Isfahan, Iran, during 2001-2010

نویسندگان [English]

  • Behnam Sanei 1
  • Mohsen Mahmoudieh 1
  • Mohammad Hossein Nasr-Esfahani 2
1 Associate Professor, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: The incidence of colon cancers is more than any other types of malignancies; however, they have severe symptoms and poor prognosis. The aim of this study was to determine the survival and recurrence rate among patients with colon cancers reffered to Alzahra hospital, Isfahan, Iran, during 2001-2010.Methods: This study was performed on 100 patients. Hospital records were used to gather information about each patient and in cases with missing information about their current status, patient's address or phone number were used to resolve the shortcomings. Kaplan-Meier method was used to determine the survival rate and log rank test to compare survival rates.Findings: 36 patients (36%) were women and 64 (64%) were men. One-year and 5-year survival was 89% and 47%, respectvely. Moreover, 54% of patients were alive and mean and median survival time was 57.78 and 62.00 months (4.81 and 5.17 years), respectvely. It was also found that only receiving chemotherapy after surgery and local recurrence had significant impact on survival (P < 0.050). Furthermore, in local recurrence, only 22% of patients relapsed; gender, stage of disease, liver metastases, patient's current status, and involvement of lymph nodes in patients with colon cancer had impact on recurrence rate (P < 0.050).Conclusion: This study showed that disease stage, chemotherapy after surgery, local recurrence, and lymph node involvement are effective on patient's survival. Therefore, early diagnosis and combined treatment could increase survival rate in patients with colon cancers.

کلیدواژه‌ها [English]

  • Survival
  • Recurrence
  • Colon Cancer

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مجله دانشکده پزشکی اصفهان
دوره 35، شماره 431 - شماره پیاپی 431
خرداد و تیر 1396
صفحه 598-608

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سابقه مقاله

  • تاریخ دریافت: 12 مرداد 1394
  • تاریخ بازنگری: 01 اردیبهشت 1403
  • تاریخ پذیرش: 17 فروردین 1401

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