بررسی برهم‌کنش پروتئین متصل شونده به عامل رشد شبه انسولینی نوع 3 در سیستم غیر وابسته به عامل رشد شبه انسولینی

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه بیوشیمی بالینی، دانشکده‌ی داروسازی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 دانشجوی دکتری تخصصی، گروه بیوشیمی بالینی، دانشکده‌ی داروسازی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 دانشیار، گروه بیوشیمی بالینی، دانشکده‌ی داروسازی و مرکز تحقیقات بیوانفورماتیک، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

پروتئین متصل شونده به عامل رشد شبه انسولینی نوع 3 (Insulin-like growth factor binding protein 3 یا IGFBP3) فراوان‌ترین نوع از خانواده‌ی IGFBPs است که با تمایل بالایی به عوامل رشد شبه انسولینی متصل می‌شود و عملکرد آن‌ها را تحت تأثیر قرار می‌دهد. تحقیقات نشان می‌دهد IGFBP3 در بسیاری از بیماری‌ها همچون دیابت، بیماری آلزایمر و سرطان دخالت دارد؛ به ‌طوری‌که در بسیاری از بیماری‌ها در اثر عواملی نظیر پروتئولیز و یا هایپرمتیلاسیون، پروموتر (Promoter) آن کاهش می‌یابد. در نتیجه، با آزاد شدن عامل رشد شبه انسولینی-1 و در دسترس قرار گرفتن آن‌، سبب پیشرفت تومورزایی و سرطان می‌گردد. اثر سرکوب‌کنندگی IGFBP3 بر روی سرطان به دو روش فعالیت وابسته به و غیر وابسته به عامل رشد شبه انسولینی اعمال می‌شود. به تازگی، نقش حیاتی عملکرد IGFBP3 مستقل از عامل رشد شبه انسولینی مورد توجه قرار گرفته است. با وجود تحقیقات گسترده در این زمینه، هنوز نقش این مسیر به‌ طور کامل مشخص نیست. اگر چه گمان می‌رود که IGFBP3 به‌ صورت مستقل با توانایی اتصال به گیرنده‌های هسته‌ای همچون گیرنده‌های رتینوئیدی X، گیرنده‌ی فعال ‌کننده‌ی رشد پروکسیزومی γ، Nur77، گیرنده‌ی ویتامین D و یا گیرنده‌های سطح سلولی همچون Transmembrane protein 219 (TMEM219)، پروتئین مربوط به لیپوپروتئین با چگالی پایین نوع 1 و گیرنده‌ی عامل رشد اپیدرمی سبب القای آپوپتوز می‌شود.

کلیدواژه‌ها

عنوان مقاله [English]

The Interaction of Insulin-Like Growth Factor Binding Protein 3 (IGFBP-3) in Insulin-Like Growth Factor (IGF)-Independent System

نویسندگان [English]

  • Amir Ansari 1
  • Ali Gheysarzadeh 2
  • Mohammad Reza Mofid 3
1 MSc Student, Department of Medical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2 PhD Student, Department of Medical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
3 Associate Professor, Department of Medical Biochemistry, School of Pharmacy and Pharmaceutical Sciences AND Bioinformatics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Insulin-like growth factor-binding protein 3 (IGFBP-3) is the most abundant IGFBP in circulation, interacts with high affinity to IGFs altering their function. Emerging evidence has indicated that IGFBP3 mostly involved in human disease such as diabetes, Alzheimer's disease, and cancer. It has been determined that IGFBP3 expression is decreased in various cancer cell lines by promoter methylation and proteases digestion. Therefore, bioavailable form of IGF-I increases in circulation promoting the tumorigenesis and progression of cancer. IGFBP3 function in cancer suppressing can be divided in two ways: IGF-dependent, and IGF-independent action. Recently it has been shown that IGFBP3 has vital roles independent of IGFs. Despite decades of unremitting research, this function of IGFBP-3 has not been clarified. However, it has been suggested that IGFBP3 independently can bind to its receptors in the nucleus including retinoid receptors (RXRs) peroxisome proliferator activated receptors (PPARγ), Nur77 vitamin D response (VDR), and/or cell surface receptors such as transmembrane protein 219 (TMEM219), low-density lipoprotein receptor-related protein 1 (LRP-1), and epidermal growth factor receptor (EGFR) inducing apoptosis. In this review, we described further mechanisms of IGF-independent action of IGFBP3.

کلیدواژه‌ها [English]

  • Insulin-like growth factor binding protein 3
  • Apoptosis
  • Cancer

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مجله دانشکده پزشکی اصفهان
دوره 35، شماره 451 - شماره پیاپی 451
آذر و دی 1396
صفحه 1452-1461

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  • تاریخ دریافت: 03 مهر 1396
  • تاریخ بازنگری: 30 فروردین 1403
  • تاریخ پذیرش: 17 فروردین 1401

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