بررسی بروز Psoriasis در بیماران مبتلا به لوپوس اریتماتوی سیستمیک فعال

صفائی, علی; کریمی‌فر, منصور; موسوی, حمیدرضا; بافنده, بهزاد

doi:10.22122/jims.v36i489.10329

بررسی بروز Psoriasis در بیماران مبتلا به لوپوس اریتماتوی سیستمیک فعال

نوع مقاله : مقاله های پژوهشی

نویسندگان

¹ دانشجوی پزشکی، کمیته‌ی تحقیقات دانشجویی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

² دانشیار، گروه داخلی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

³ فوق تخصص روماتولوژی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

⁴ متخصص پوست، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

10.22122/jims.v36i489.10329

چکیده

مقدمه: بروز هم‌زمان لوپوس اریتماتوی سیستمیک (Systemic lupus erythematosus یا SLE) فعال و Psoriasis نادر است، اما با توجه به درگیری پوستی شایع در هر دو و تشدید Psoriasis با درمان‌های ضد مالاریا جهت SLE، بررسی بروز هم‌زمان دو بیماری اهمیت دارد. مطالعه‌ی حاضر، با هدف بررسی بروز Psoriasis در جمعیت افراد با SLE فعال انجام شد.روش‌ها: مطالعه‌ی حاضر از نوع مقطعی بود که بر روی 148 نفر از بیماران مبتلا به SLE فعال، در سال‌های 96-1394 انجام گرفت. فعالیت SLE در بیماران طبق سیستم امتیازدهی Systemic lupus erythematosus disease activity index-2K (SLEDAI-2K) بررسی شد و سپس، بروز Psoriasis در بیماران بررسی گردید. اطلاعات دموگرافیک بیماران نیز در چک لیست مربوط ثبت شد.یافته‌ها: میانگین امتیاز SLEDAI-2K در بیماران مورد ارزیابی 77/19 ± 10/14 بود. مدت زمان ابتلا به SLE با امتیاز SLEDAI-2K ارتباط معنی‌داری داشت (294/0 = r، 001/0 = P). بیماری Psoriasis از نظر توزیع جنسیتی تفاوت معنی‌داری داشت (019/0 = P). بین سن بیماران (080/0 = P)، مدت زمان ابتلا به SLE (316/0 = P) و میانگین نمره‌ی SLEDAI-2K (295/0 = P) با ابتلای هم‌زمان به Psoriasis ارتباط معنی‌داری وجود نداشت.نتیجه‌گیری: میانگین سنی بیماران، مدت زمان SLE و میانگین امتیاز فعالیت آن ارتباطی با ابتلای هم‌زمان به Psoriasis نداشتند، اما توزیع جنسیتی Psoriasis در بیماران با SLE فعال، به طور احتمالی در مردان بیشتر است.

کلیدواژه‌ها

عنوان مقاله [English]

Assessment of Psoriasis Incidence in Patients with Active Systemic Lupus Erythematosus

نویسندگان [English]

Ali Safaei ¹
Mansour Karimifar ²
Hamid Reza Mousavi ³
Behzad Bafandeh ⁴

¹ Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

² Associate Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

³ Rheumatologist, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

⁴ Dermatologist, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

چکیده [English]

Background: Coincidence of systemic lupus erythematosus (SLE) and psoriasis is rare, but by consideration of skin involvement in both diseases and exacerbation of psoriasis with routine anti-malaria remedies used for lupus, assessment of coincidence of two diseases is important. In the current study, coincidence of psoriasis in cases with active SLE was assessed.Methods: This was a cross-sectional study on 148 cases with active SLE performed during the years 2015-17. Lupus activity was assessed based on Systemic Lupus Erythematosus Disease Activity Index-2K (SLEDAI-2K). Then, psoriasis was evaluated in patients. Demographics of patients were recorded as well.Findings: Mean score of SLEDAI-2K was 19.77 ± 14.10. Duration of SLE and score of SLEDAI-2K had significant association (P = 0.001, r = 0.294). Gender distribution in psoriasis was significant (P = 0.019). There was no association between psoriasis and patients' age (P = 0.08), duration of SLE (P = 0.316), and SLEDAI-2K score (P = 0.295).Conclusion: Mean age of patients, duration of SLE, and mean score of lupus activity were not in association with coincidence of psoriasis and SLE, but gender distribution of psoriasis among patients with active SLE was probably more among men.

کلیدواژه‌ها [English]

Systemic Lupus Erythematosus
Psoriasis
Skin Diseases

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