ارزیابی ارتباط بین برخی عوامل خطر و ابتلا به سرطان کلورکتال

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 استادیار، گروه پزشکی اجتماعی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 دانشجوی پزشکی، کمیته‌ی تحقیقات دانشجویی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 متخصص طب کار، اصفهان، ایران

چکیده

مقدمه: سرطان کلورکتال، از شایع‌ترین سرطان‌های گوارشی است. هدف از انجام این مطالعه، بررسی ارتباط برخی عوامل خطر کمتر مطالعه شده در ارتباط با سبک زندگی، کیفیت خواب و فعالیت فیزیکی با سرطان کلورکتال بود.روش‌ها: مطالعه‌ی حاضر، یک مطالعه‌ی مقطعی بود که در بیمارستان الزهرای (س) اصفهان در سال 1397 انجام شد. تعداد 50 نفر از بیماران بستری با تشخیص قطعی و اخیر سرطان کلورکتال و تعداد 42 نفر از بستگان درجه‌ی یک بیماران گروه بیمار به عنوان گروه سالم اول و تعداد 58 نفر از سایر بیمارانی که هم‌زمان با تشخیصی غیر از سرطان بستری شده بودند، به عنوان گروه سالم دوم انتخاب شدند. خصوصیات دموگرافیک، مصرف دخانیات، الکل، فست‌فود و نوشیدنی‌های گازدار، سطح فعالیت فیزیکی با فرم کوتاه پرسش‌نامه‌ی International physical activity questionnaire (IPAQ) و کیفیت خواب با پرسش‌نامه‌ی Pittsburgh، برای هر فرد تکمیل شد. با آزمون 2χ و One-way-ANOVA، واکاوی متغیرها بین سه گروه انجام گرفت و سپس، متغیرهای با 250/0 > P، وارد مدل Logistic regression شدند و نسبت شانس برای هر یک از عوامل خطر محاسبه شد.یافته‌ها: سن، سطح تحصیلات و شاخص توده‌ی بدنی بالاتر و عدم ابتلا به دیابت و سابقه‌ی کوله‌سیستکتومی در گروه بیمار بالاتر از هر دو گروه سالم بود، اما این اختلاف از نظر آماری معنی‌دار نبود (050/0 < P). ابتلا به سرطان کلورکتال در گروه بیمار نسبت به گروه سالم اول (با نسبت شانس معادل 86/2) و همچنین، گروه بیمار نسبت به گروه سالم دوم (با نسبت شانس معادل 57/3) در مردان نسبت به زنان به طور معنی‌داری بالاتر بود (050/0 > P).نتیجه‌گیری: شانس ابتلا به سرطان کلورکتال در مردان بالاتر از زنان می‌باشد.

کلیدواژه‌ها


عنوان مقاله [English]

The Relationship between Some Risk Factors and Colorectal Cancer

نویسندگان [English]

  • Negah Tavakolifard 1
  • Ehsan Iravani 2
  • Alireza Mortazavi 3
1 Assistant Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Occupational Medicine Specialist, Isfahan, Iran
چکیده [English]

Background: Colorectal cancer (CRC) is one of the most common cancers of gastrointestinal system. The purpose of this study was to determine the relationship between some of less-studied life style risk factors, sleep quality and the level of physical activity, with colorectal cancer.Methods: This cross-sectional study was conducted in Alzahra hospital, Isfahan, Iran. 50 newly diagnosed patients with colorectal cancer were entered from admitted patients considering as the patient group, 42 first-degree relatives of them as 1st healthy group, and 58 admitted patients without any cancer diagnosis (randomly selected) as the 2nd healthy group. Demographic characteristics, smoking, alcoholic beverages and carbonated drinks intake, fast food consumption, physical activity level [based on International Physical Activity Questionnaire (IPAQ) short form] and sleep quality (based on Pittsburg Sleep Quality Questionnaire) were collect by the researcher. Variables were analyzed using chi-square and one-way ANOVA tests, then variables with P-value of less than 0.250 were analyzed through multivariate logistic regression model, and the odds ratio (OR) of each factor was calculated.Findings: Age, level of education, and body mass index (BMI), as well as no history of diabetes mellitus and positive history of cholecystectomy were higher in the patient group than in the two healthy groups; but the differences were not statistically significant (P > 0.050). Male gender was significantly associated with OR of colorectal cancer in patient group compared with both healthy groups (OR = 2.86 and OR = 3.57 with 1st and 2nd healthy groups, respectively).Conclusion: The risk of colorectal cancer is higher in men than in women.

کلیدواژه‌ها [English]

  • Colorectal Cancer
  • Sleep quality
  • Life-style
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