مجله دانشکده پزشکی اصفهان

مجله دانشکده پزشکی اصفهان

تأثیر هشت هفته تمرینات تناوبی شدید بر گیرنده‌ی کینازی نوع II قلب و سطوح پلاسمایی میوستاتین Ratهای نر

نوع مقاله : مقاله های پژوهشی

نویسندگان
مجید بیگی 1
سعید کشاورز 2
جمشید بنایی 3
حمید زاهدی 4
1 دانشجوی دکتری، گروه علوم ورزشی و تربیت بدنی، واحد نجف‌آباد، دانشگاه آزاد اسلامی، نجف‌آباد، ایران
2 استادیار، گروه علوم ورزشی و تربیت بدنی، واحد نجف‌آباد، دانشگاه آزاد اسلامی، نجف‌آباد، ایران
3 استادیار، مرکز تحقیقات طب ورزش، واحد نجف‌آباد، دانشگاه آزاد اسلامی، نجف‌آباد، ایران
4 استادیار، مرکز تحقیقات طب ورزش، واحد نجف‌آباد، دانشگاه آزاد اسلامی، اصفهان، ایران
10.22122/jims.v38i561.12718
چکیده
مقدمه: فعالیت ورزشی با تغییر در غلظت عوامل رشدی و گیرنده‌های آن، ممکن است اثرات مفیدی برای عضله‌ی قلبی داشته باشد. از این رو، هدف از انجام مطالعه‌ی حاضر، بررسی تأثیر هشت هفته تمرینات تناوبی شدید بر گیرنده‌ی کینازی نوع II قلب و سطوح پلاسمایی میوستاتین Ratهای نر بود.روش‌ها: تعداد 20 سر موش صحرایی نر با محدوده‌ی سنی سه ماه، بعد از گذراندن دوره‌ی آشناسازی، به صورت تصادفی به دو گروه شاهد (10 = n) و مورد یا تمرین تناوبی شدید (10 = n) تقسیم شدند. تمرینات تناوبی شدید با شدت 95-85 درصد و شیب 20 درجه در مدت زمان 80 دقیقه در طول هشت هفته و هر هفته پنج جلسه به طول انجامید. میوستاتین به روش Enzyme-linked immunosorbent assay (ELISA) و گیرنده‌ی کینازی نوع II بطن چپ قلب به روش Immunohistochemistry (IHC) اندازه‌گیری شد. داده‌‌های به دست آمده توسط آزمون Independent t در سطح معنی‌‌داری 050/0 > P تجزیه و تحلیل شدند.یافته‌ها: با مقایسه‌ی بین گروهی، اختلاف معنی‌داری در متغیر میوستاتین میان گروه‌های مورد و شاهد دیده شد (001/0 = P)، اما اختلاف معنی‌داری میان گروه‌‌ها در گیرنده‌ی کینازی نوع II قلب مشاهده نشد (820/0 = P).نتیجه‌گیری: با احتیاط به نظر می‌رسد تمرینات تناوبی شدید، اثرات مطلوبی بر کاهش میوستاتین دارد، اما بر گیرنده‌ی کینازی نوع II قلب تأثیری ندارد.
کلیدواژه‌ها
تمرینات تناوبی شدید
گیرنده‌ی کینازی نوع II
میوستاتین
Ratهای نر

عنوان مقاله English

The Effect of Eight Weeks of High-Interval Training on Activin Receptor Type II in Heart and Plasma Levels of Myostatin in Male Rats

نویسندگان English

Maijd Beigi 1
Saeed Keshavarz 2
Jamshid Banaei 3
Hamid Zahedi 4
1 PhD Student, Department of Sport Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran
2 Assistant Professor, Department of Sport Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran
3 Assistant Professor, Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran
4 Assistant Professor, Sport Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran
چکیده English

Background: Exercise trainings have beneficial effects on myocardium by changing the concentration of growth factors and their receptors. The aim of this study was to determine the effect of eight weeks of high-intensity interval training on activin receptor type II in heart and plasma levels of myostatin in male rats.Methods: After the familiarization period, twenty male rats with the limitation of three months of age were randomly divided to control (n = 10) and high-intensity interval training (n=10) groups. High-intensity interval training was continued for eight weeks, five sessions in each week and each session lasted 80 minutes with 85-90 percent intensity of rats’ power with 20-degree ramp. Activin receptor type II in the myocardial left ventricle was measured using immunohistochemistry method, and myostatin was measured by the enzyme-linked immunosorbent assay (ELISA) method. The data were analyzed using independent-samples t test at the statistically significant level of P < 0.050.Findings: In between groups comparison, there was a significant difference between the high-intensity interval training and control groups in myostatin variable (P = 0.001). There was no significant difference between the groups in myocardium activin receptor type II (P = 0.820).Conclusion: It cautiously seems that high-intensity interval training have desirable effects on reducing myostatin, but it has no effect on heart activin receptor type II.

کلیدواژه‌ها English

High-intensity Intermittent Exercise
Activin receptors
Myostatin
Male
Rats
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مجله دانشکده پزشکی اصفهان
دوره 38، شماره 561 - شماره پیاپی 561
فروردین و اردیبهشت 1399
صفحه 8-13

  • تاریخ دریافت 19 بهمن 1398
  • تاریخ پذیرش 17 فروردین 1401