نوع مقاله : مقاله های پژوهشی
1 گروه تربیت بدنی و علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران
2 استادیار، گروه تربیت بدنی و علوم ورزشی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران
3 استادیار، مرکز تحقیقات فراوردههای طبیعی و گیاهان دارویی، دانشگاه علوم پزشکی خراسان شمالی، بجنورد، ایران
عنوان مقاله [English]
Background: The present study aimed to evaluate the effect of intense continuous and interval training on the levels of Brain-Derived Neurotrophic Factor (BDNF) and Tumor Necrosis Factor Alpha (TNF-α) in hippocampus of old rats.Methods: 30 old male Wistar rats (18 weeks old) were divided into 3 groups of interval training, continuous training, and control. Continuous training was performed for 8 weeks with 65% to 70% VO2max and interval training was performed 8 weeks with 5-8 repetitions of 2 minutes of working with 80%-100% VO2max and 2 minutes active rest with 50% of VO2max. Hippocampal samples were extracted 48 hours after the last training session to measure protein levels of BDNF and TNF-α. One-way ANOVA and Tukey post hoc tests were used for data analysis.Findings: Hippocampus BDNF levels in continuous (P = 0.002) and interval training (P = 0.003) groups were significantly higher than the control group. But no significant differences were found in BDNF levels between continuous and interval training groups (P = 0.361). TNF-α levels in continuous and interval training groups were significantly higher than the control group (P = 0.001 for both). But no significant differences were found in TNF-α levels between continuous and interval training groups (P = 0.639).Conclusion: Intense continuous and interval training increase BDNF levels in the hippocampus of the elderly rats through increasing TNF-α levels; thus, intense continuous and interval training can prevent aging of the nervous system by improving BDNF levels.