بهبود استخراج لایه‌ی Retinal Pigment Epithelium (RPE) در تصاویر Optical Coherence Tomography (OCT) با استفاده از روش قطعه‌ای برنامه‌نویسی پویا در بیماران دچار جداشدگی اپی‌تلیال رنگدانه

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه بیوالکتریک، دانشکده‌ی فن‌آوری‌های نوین علوم پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

2 استادیار، گروه بیوالکتریک، دانشکده‌ی فن‌آوری‌های نوین علوم پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

3 دانشیار، گروه چشم پزشکی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران

چکیده

مقدمه: تخریب ماکولایی وابسته به سن (Age-related macular degeneration یا AMD) یکی از اختلالات به وجود آمده در شبکیه است که موجب اختلال بینایی مرکزی می‌گردد. جهت تشخیص این بیماری از تصاویر Optical coherence tomography (OCT) استفاده می‌شود و با توجه به تغییرات به وجود آمده‌ی ناشی از بیماری به صورت ایجاد بالازدگی‌هایی در لایه‌ی Retinal pigment epithelium (RPE) شبکیه، عارضه مورد تشخیص قرار می‌گیرد.روش‌ها: در روش پیشنهادی، نقطه‌ی ابتدایی لایه‌ی RPE در تعداد محدودی از اسلایدهای OCT توسط کاربر علامت‌گذاری می‌شود تا احتمال تشخیص اشتباه لایه‌های دیگر مانند Retinal nerve fiber layer (RNFL) از بین برود. سپس، الگوریتم مبتنی بر گراف بر مبنای برنامه‌نویسی پویا در قطعات کم عرض به تصویر اعمال شده، الگوریتمی برای حفظ پیوستگی قطعات استفاده شد تا در نهایت، مکان لایه‌ی RPE تخمین زده شود. با الگوریتمی مشابه، لایه‌ی Bruch نیز در هر اسکن مکان‌یابی شد و با تخمین فاصله‌ی دو لایه، بالازدگی‌های Persistent epithelial defect (PED) شناسایی گردید.یافته‌ها: روش پیشنهادی بر روی سه دیتاست با تعداد 35، 15 و 10 بیمار بررسی شد. در مقایسه با روش مبتنی بر گراف در دیتاست اول، دوم و سوم میزان خطای بدون علامت در لایه‌ی RPE به ترتیب از 3392/4 به 7827/2، از 3340/3 به 1623/2 و از 4842/6 به 3924/2 پیکسل و در لایه‌ی Bruch از 7576/5 به 8473/4، از 3353/4 به 6023/2 و از 67/6 به 5446/2 پیکسل بهبود یافت.نتیجه‌گیری: روش پیشنهادی در تصاویر سالم و دارای PED قابل اعتبار است و می‌تواند در امر تشخیص بیماری AMD مؤثر واقع شود.

کلیدواژه‌ها

عنوان مقاله [English]

The Improvement of Extraction Retinal Pigment Epithelium (RPE) Layer in Optical Coherence Tomography (OCT) Images by Using Piecewise Dynamic Programming Method in Patients with Persistent Epithelial Defect (PED)

نویسندگان [English]

  • Alireza Haghani 1
  • Rahele Kafieh 2
  • Mohammadreza Akhlaghi 3
1 MSc Student, Department of Bioelectric, School of Advanced Technologies in Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Department of Bioelectric, School of Advanced Technologies in Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
3 Professor, Department of Ophthalmology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده [English]

Background: Age-related macular degeneration (AMD) is one of the disorders in the retina that causes central vision disorders. Optical coherence tomography (OCT) images are used to diagnose this disease, and given the changes in the disease caused by elevations in the retinal pigment epithelium (RPE) layer of the retina, the complication is diagnosed.Methods: In the proposed method, the starting point of the RPE layer was labeled by the user on a limited number of OCT slides to eliminate the possibility of mistaking other layers such as the retinal nerve fiber layer (RNFL). The graph-based algorithm was then applied to the image in low width parts; an algorithm was used to maintain the continuity of the parts to eventually estimate the location of the RPE layer. With a similar algorithm, the bruch layer was also located at each scan, and by estimating the distance of the two layers, PED elevations were identified.Findings: The proposed method was evaluated on three datasets with 35, 15, and 10 patients. Compared to the graph-based method in the first, second, and third datasets, respectively, the unsigned error in the RPE layer improved from 4.3392 to 2.7827, 3.3340 to 2.1623, and 6.4842 to 2.3924 pixels, and the bruch layer improved from 5.7576 to 4.8473, 4.3353 to 2.6023, and 6.67 to 2.5446 pixels, respectively.Conclusion: The proposed method is valid in PED images, and can be effective in diagnosing AMD.

کلیدواژه‌ها [English]

  • Retinal pigment epithelium
  • Optical coherence tomography
  • Age-related macular degeneration
  • Retinal pigment epithelial detachment

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  • تاریخ دریافت: 13 مرداد 1400
  • تاریخ بازنگری: 31 فروردین 1403
  • تاریخ پذیرش: 17 فروردین 1401

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