Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparison of Breast Tumor Size Measurement Using Ultrasound and Mammography with Pathologic Report Following Mastectomy or Lumpectomy

Document Type : Original Article (s)

Authors
Behnoosh Mohammadi-Jazi 1
Pardis Makhmali 2
1 Assistant Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Medical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.48305/jims.v40.i681.0578
Abstract
Background: One of the most important factors in determining prognosis and therapeutic plan in patients with breast cancer is tumor size. Our aim in this study was to compare the estimated tumor size in two common imaging modalities, ultrasound and mammography with pathologic assessment.
Methods: In this cross sectional study, we analyzed 287 patients with breast cancer diagnosis whose pathologic specimen was reported in pathology department of Omid hospital (Isfahan, Iran) from March 2015 to March 2020. The difference in tumor size were evaluated based on imaging and pathological reports. Then, we classified them in three groups as concordant, underestimated, and overestimated for which the effect of various factors such as age, tumor type, T stage and molecular subtype on accuracy of each modality was assessed.
Findings: Concordance rate was 58.3% in ultrasonography and 51.7% in mammography. Ultrasonography and mammography respectively underestimated the tumor size in 30.6% and 31%, and overestimated in 11.1% and 17.2% of cases indicating no statistically significant difference between the two modalities. Ultrasonography and mammography underestimate large tumors more commonly than small tumors. For tumors smaller than 20 mm and HER2- tumors, ultrasonography is more accurate than mammography. Also, mammography estimates the size of Luminal A tumors compared to ultrasound.
Conclusion: There was no significant difference between the accuracy of ultrasonography and mammography measurement of tumor size, but inherent factors such as T stage, her2 expression and molecular subtype influence this issue.
Keywords
Breast density
Breast neoplasms
Mastectomy
Mammography
Ultrasonography
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Journal of Isfahan Medical School
Volume 40, Issue 681
1st Week, October
Autumn 2022
Pages 578-586

  • Receive Date 28 September 2022