تأثیر 10 هفته تمرینات ترکیبی در آب بر سالخوردگی سیستم ایمنی رت‌های سالمند

نوع مقاله : مقاله های پژوهشی

نویسندگان

1 دانشجوی دکتری دانشگاه حکیم سبزواری، دانشکده‌ی تربیت بدنی و علوم ورزشی، گروه فیزیولوژی ورزشی، سبزوار، ایران

2 دانشیار دانشگاه حکیم سبزواری، دانشکده‌ی تربیت بدنی و علوم ورزشی، گروه فیزیولوژی ورزشی، سبزوار، ایران

3 استاد دانشگاه حکیم سبزواری، دانشکده‌ی تربیت بدنی و علوم ورزشی، گروه فیزیولوژی ورزشی، سبزوار، ایران

4 استادیار دانشگاه حکیم سبزواری، دانشکده‌ی علوم پایه، گروه زیست‌شناسی، سبزوار، ایران

10.48305/jims.v40.i694.0890

چکیده

مقاله پژوهشی




مقدمه: مجموعه‌ای از لنفوسیت‌های بکر سالخورده و انحلال تیموس از عوامل اصلی ایجادکننده‌ی سالخوردگی سیستم ایمنی هستند که با تمرین ورزشی می‌توان این عوامل را تعدیل کرد. بنابراین هدف از پژوهش حاضر، بررسی 10 هفته تمرین ترکیبی در آب بر سالخوردگی سیستم ایمنی در رت‌های سالمند می‌باشد.
روش‌ها: 16 رت 24 ماهه با میانگین وزن 5 ± 320 گرم به صورت تصادفی به دو گروه تمرین ترکیبی (8 = n) و شاهد (8 = n) تقسیم شدند. تمرینات ترکیبی
4 جلسه در هفته (دو روز استقامتی و دو روز مقاومتی) در ظرفی به ابعاد 50×50×100 سانتی‌متر با آب 1 ± 30 درجه‌ی سانتی‌گراد اجرا شد. داده‌ها توسط آزمون واریانس یک طرفه آنالیز شدند.
یافته‌ها: کاهش معنی‌داری در گروه تمرین نسبت به کنترل در وزن تیموس و شاخص‌های مربوط به لنفوسیت‌های TCD8+ سالخورده و TCD8+ و TCD4+ بکر سالخورده مشاهده شد (0/01 = P). همچنین افزایش معنی‌داری در شاخص‌های CD4+ و CD8+ و شاخص‌های مربوط به لنفوسیت‌های TCD8+ و TCD4+ بکر وجود داشت (01/0 = P). در حالی‌که بین نسبت شاخص‌های CD8+/CD4+ و شاخص‌های مربوط به لنفوسیت‌های TCD4+ سالخورده تفاوت معنی‌داری مشاهده نشد (به ترتیب 0/48 = P و 0/19 = P).
نتیجه‌گیری: نتایج این مطالعه پیشنهاد می‌کند، تمرینات ترکیبی در آب، یک فعالیت ایمن برای سالمندان به منظور بهبود سیستم ایمنی و کاهش سالخوردگی سلول‌های T می‌باشد.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of 10 Weeks Combined Training in Water on Immunosenescence in Elderly Rats

نویسندگان [English]

  • Mohammad Jahanmahin 1
  • Roya Askari 2
  • Amirhosein Haghighi 3
  • Taktom Hajjar 4
1 PhD Student of Hakim Sabzevari University, School of Physical Education & Sport Sciences, Department of Exercise Physiology, Sabzevar, Iran
2 Associate Professor of Exercise Physiology, Department of Exercise Physiology, School of Physical Education & Sport Sciences, University of Hakim Sabzevari, Sabzevar, Iran
3 Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education & Sport Sciences, University of Hakim Sabzevari, Sabzevar, Iran
4 Assistant Professor of Hakim Sabzevari University, Department of Basic Sciences, School of Biology, Sabzevar, Iran
چکیده [English]

Background: A complex of restricted naïve lymphocytes in conjunction with an age-associated accumulation of senescent T cells and/or thymic involution are major contributors to immunosenescence, which can be modulated by exercise training. Therefore, the present study aims to investigate 10 weeks of combined training in water on immunosenescence in elderly rats.
Methods: 16 rats for 24 months with mean weight 320 ± 5gr were randomly distributed into a control group
(n = 8) and combined training (n = 8). Combined training was performed in 4 sessions per week (two endurance days and two resistance days) in a container with dimensions of 50×50×100 centimeter with water at 30 ± 1 ºC. Data were analyzed by one-way ANOVA test.
Findings: A significant decrease was observed in training groups than control in thymus weight and indicators related to senescent TCD8+ and senescent naïve TCD8+ and TCD4+ (P = 0.01), as well as, there was a significant increase in indicators related to CD4+ and CD8+ and naïve TCD8+ and TCD4+ lymphocytes
(P = 0.01). While wasn't observed significant difference between CD4+/CD8+ ratio and indicators related to senescent TCD4+ (P = 0.48 and P = 0.19, respectively).
Conclusion: The results of this study suggest that combined training in water is a safe activity for the elderly to improve the immune system and reduction of senescence-prone T cells.

کلیدواژه‌ها [English]

  • Aged
  • Combined training
  • Circuit-based exercise
  • Immunosenescence
  • T lymphocytes
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