مجله دانشکده پزشکی اصفهان

مجله دانشکده پزشکی اصفهان

مقایسه‌ی دوز حلزون گوش در بیماران مبتلا به سرطان سر و گردن تحت درمان با رادیوتراپی سه بعدی انطباقی و توموتراپی حلزونی

نوع مقاله : مقاله های پژوهشی

نویسندگان
حسین رست 1
سیمین همتی 2
ناهید شامی 3
محسن صائب 4
محمدباقر توکلی 5
1 دانشجوی کارشناسی ارشد، گروه فیزیک پزشکی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
2 دانشیار، گروه رادیوانکولوژی، دانشکده‌ی پزشکی، بیمارستان سیدالشهدا، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
3 کارشناسی ارشد فیزیک پزشکی، بیمارستان سیدالشهدا، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
4 دکتری فیزیک پزشکی، گروه فیزیک پزشکی، دانشکده‌ی پزشکی، اصفهان، ایران
5 استاد، گروه فیزیک پزشکی، دانشکده‌ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
10.48305/jims.v41.i710.0124
چکیده
مقاله پژوهشی




مقدمه: سرطان سر و گردن (Head and neck cancer) جزء ده سرطان شایع در سراسر جهان است. به دلیل پیچیدگی آناتومی سر و گردن، در هنگام پرتودرمانی اندام‌های زیادی دوز دریافت می‌کنند. هدف این مطالعه، مقایسه‌ی دوز رسیده به حلزون گوش در دو روش (Three-Dimensional Conformal Radiotherapy) 3D-CRT و (Helical Tomotherapy) HT بود.
روش‌ها: مطالعه‌ی حاضر کاربردی و مقطعی است. 28 بیمار که دارای سرطان نازوفارنکس بوده و به بیمارستان سیدالشهدا (امید) برای درمان بین سال‌های 1399-1401 مراجعه کرده و کاندید درمان با یکی از دستگاه‌های 3D-CRT و یا HT می‌باشند؛ در این مطالعه قرار گرفتند. طرح درمانی برای هر بیمار در دو دستگاه، شبیه‌سازی ‌شده و سپس متغیرهای مطالعه مانند حداکثر و میانگین دوز و شاخص‌های همگنی و انطباق مورد بررسی قرار گرفتند.
یافته‌ها: با مقایسه‌ی طرح‌های درمانی HT و 3D-CRT، میانگین دوز قابل دریافت حلزون گوش و سایر اندام‌‌های در معرض خطر در روش HT نسبت به روش 3D-CRT کاهش یافته و تفاوت قابل‌توجهی داشته‌اند، که نشان می‌دهد اختلاف معنی‌داری بین دو روش وجود دارد.
نتیجه‌گیری: طبق داده‌های مطالعه‌ی ما روی بیماران مبتلا به سرطان نازوفارنکس، نتایج نشان داد که HT از همگنی و انطباق هدف بهتری برخوردار است و دوز تحویلی به (Organ At Risk) OARها را در مقایسه با 3D-CRT معمولی کاهش می‌دهد.
کلیدواژه‌ها
سرطان سر و گردن
نازوفارنکس
پرتودرمانی تطبیقی
توموتراپی
حلزون گوش
موضوعات

عنوان مقاله English

Comparison of the Cochlea Dose in Head and Neck Cancer Patients Treated with 3-Dimensional Conformal Radiotherapy and Helical Tomotherapy

نویسندگان English

Hossein Rast 1
Simin Hemmati 2
Nahid Shami 3
Mohsen Saeb 4
Mohammad Bagher Tavakoli 5
1 MSc Student, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor, Department of Radio Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 MSc in Medical Physics, Omid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
4 PhD in Medical Physics, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5 Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده English

Background: Head and neck cancer (HNC) is among the ten most common cancers worldwide. Due to the complex anatomy of the head and neck, many organs receive radiation during treatment. The aim of this study is to compare the dose received by the cochlea in two different treatment methods, 3D-CRT (Three-Dimensional Conformal Radiotherapy) and HT (Helical Tomotherapy). 
Methods: The current study is applied and cross-sectional. 28 patients who had nasopharyngeal cancer and were referred to Seyed al-Shohada Hospital (Omid) for treatment between 2020-2022 and were candidates for treatment with one of the 3D-CRT or HT devices; were included in this study. The treatment plan for each patient was simulated in two devices and then study variables such as maximum and average dose and homogeneity and conformity index were investigated.
Findings: Comparison of the treatment plans using Helical Tomotherapy (HT) and Three-Dimensional Conformal Radiation Therapy (3D-CRT), Showed that the average dose received by organs at risk, such as the cochlea, was significantly lower in the HT method compared to the 3D-CRT method. This indicating a significant difference between the two treatment methods.
Conclusion: Our study on patients with nasopharyngeal cancer revealed that Helical Tomotherapy (HT) treatment led to better target homogeneity and compliance compared to conventional Three-Dimensional Conformal Radiation Therapy (3D-CRT). Additionally, HT was found to reduce the dose delivered to organs at risk (OARs) compared to 3D-CRT.

کلیدواژه‌ها English

Head and neck cancer
Nasopharynx
Conformal radiotherapy
Tomotherapy
Cochlea
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مجله دانشکده پزشکی اصفهان
دوره 41، شماره 710
هفته 2 اردیبهشت
فروردین و اردیبهشت 1402
صفحه 124-130