تأثیر تمرین ورزشی بر مارکرهای التهابی در بیماران مبتلا به مولتیپل اسکلروزیس: مروری نظام‌مند و فراتحلیل

نوع مقاله : Review Article

نویسندگان

1 استادیار، گروه علوم ورزشی، دانشکده‌ی علوم انسانی، دانشگاه کاشان، کاشان، ایران

2 دانشجو کارشناسی ارشد، گروه علوم ورزشی، دانشکده‌ی علوم انسانی، دانشگاه کاشان، کاشان، ایران

3 دانشیار، گروه علوم ورزشی، دانشکده‌ی علوم انسانی، دانشگاه کاشان، کاشان، ایران

10.48305/jims.v41.i749.1116

چکیده

مقاله مروری




مقدمه: بیماری مولتیپل اسکلروزیس (Multiple sclerosis) MS، یک بیماری پیش‌رونده‌ی التهابی می‌باشد که ماکرهای التهابی نقش مؤثری در گسترش این بیماری دارند. در مقابل، تمرین ورزشی ممکن است منجر به بهبود التهاب مزمن شود. با این وجود اثر تمرین ورزشی بر مارکرهای التهابی در این بیماران به وضوح درک نشده است. از این‌رو، هدف فراتحلیل حاضر بررسی تأثیر تمرین ورزشی بر سایتوکین‌های التهابی IL-6، TNF-α و IL-10 و همچنین CRP در بیماران مبتلا به MS می‌باشد.
روش‌ها: جستجوی نظامند در 3 پایگاه اطلاعاتی اصلی PubMed، Web of Science و Scopus برای مقالات انگلیسی و فارسی منتشر شده تا تاریخ 1 دی 1401 انجام شد. به منظور تعیین اندازه‌ی اثر تمرین ورزشی در برابر گروه شاهد بر IL-6، IL-10، TNF-α و CRP از تفاوت میانگین استاندارد شده (SMD) و فاصله‌ی اطمینان 95 درصد (CIs) استفاده گردید.
یافته‌ها: 16 مطالعه شامل 687 بیمار مبتلا به MS وارد فراتحلیل شدند. تمرین ورزشی منجر به کاهش معنی‌دار سطوح IL-6 [0/002 = P، (0/14- الی 0/65CI: -) 0/40-] و CRP [0/02 = P، (0/04- الی 0/70CI: -) 0/370-] گردید، اما بر سطوح TNF-α [0/20 = P، (0/14 الی 0/68CI: -) 0/27-] و IL-10 [0/94 = P، (0/43 الی 0/40CI: -) 0/15] اثر معنی‌داری نداشت.
نتیجه‌گیری: تمرین ورزشی ممکن است منجر به بهبود وضعیت التهاب مزمن به واسطه‌ی کاهش IL-6 و CRP در بیماران مبتلا به MS شود. از این‌رو، تجویز تمرینات ورزشی منظم برای بیماران MS ممکن است رویکرد مناسبی برای مدیریت بیماری باشد.

تازه های تحقیق

موسی خلفی: Google Scholar 

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The Effect of Exercise Training on Inflammatory Markers in Patients with Multiple Sclerosis: A Systematic Review and Meta-Analysis

نویسندگان [English]

  • Mousa Khalafi 1
  • Sanaz Mohammadi Dinani 2
  • Marziye Sadat Hosseini 2
  • Keyvan Sharifmoradi 3
1 Assistant Professor, Department of Sport Sciences, School of Humanities, University of Kashan, Kashan, Iran
2 MSc Student, Department of Sport Sciences, School of Humanities, University of Kashan, Kashan, Iran
3 Associate Professor, Department of Sport Sciences, School of Humanities, University of Kashan, Kashan, Iran
چکیده [English]

Background: Multiple sclerosis (MS) is a progressive inflammatory disease in which inflammatory markers play an effective role in the development of this disease. In contrast, exercise training may lead to improved chronic inflammation. However, the effect of exercise training on inflammatory markers is not clearly understood. Therefore, the purpose of this meta-analysis is to investigate the effect of exercise training on IL-6, TNF-α, and IL-10 as well as CRP in patients with MS.
Methods: A comprehensive search was conducted in the three principal databases of PubMed, Web of Science, and Scopus for English and Persian articles published until December 22, 2022. To determine the effect sizes of the effect of exercise training on inflammatory markers IL-6, IL-10, TNF-α, and CRP, standardized mean difference (SMD) and 95% confidence intervals (CIs) were calculated.
Findings: Sixteen studies involving 687 patients with MS were included in the meta-analysis. Exercise training resulted in a significant decrease in levels of IL-6 [P = 0.002, (CI: -0.14 to 0.65: -0.40)] and CRP [P = 0.02 -0.04 to 0.70 CI: -0.37], but did not lead a significant effect on the levels of TNF-α [P = 0.20, (0.14 to 0.68 CI: -) -0.27] and IL -10 [P = 0.94, (0.43 to 0.40 CI: -0.15)].
Conclusion: Exercise training may lead to improvement of chronic inflammation status by reducing IL-6 and CRP in patients with MS. Therefore, prescribing regular exercise may be a suitable approach for disease management in patients with MS.

کلیدواژه‌ها [English]

  • Exercise
  • Cytokines
  • Inflammation
  • C-Reactive protein
  • Interleukin-6
  • Interleukin-10
  • Tumor necrosis factor-alpha
  • Multiple sclerosis
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