مجله دانشکده پزشکی اصفهان

مجله دانشکده پزشکی اصفهان

میزان سرب خون در بیماران مبتلا به دژنراسیون ماکولا وابسته به سن

نوع مقاله : Original Article(s)

نویسندگان
مینا پولادوند 1
مصطفی فقهی 2
محمد ملک احمدی 1
فریدون فرهی 2
زهرا رمضانی 3
علی شهسواری 1
پردیس تولائی نژاد 1
1 مرکز تحقیقاتی چشم اصفهان، گروه چشم پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
2 بخش چشم پزشکی، بیمارستان امام خمینی، دانشگاه علوم پزشکی جندی شاپور اهواز، اهواز، ایران
3 بخش شیمی پزشکی، دانشگاه علوم پزشکی جندی شاپور، اهواز، ایران
10.48305/jims.v42.i786.0876
چکیده
مقاله پژوهشی




مقدمه: هدف از این مطالعه، ارزیابی سطح سرب خون در بیماران مبتلا به دژنراسیون ماکولا وابسته به سن (Age-related macular degeneration ) AMD بود.
روش‌ها: این مطالعه‌ی مورد- شاهدی، بر روی بیماران مبتلا به AMD و افراد سالم در شهر اهواز استان خوزستان در ایران انجام شد. گروه شاهد به صورت تصادفی از کلینیک سرپایی عمومی انتخاب شدند. دو گروه برای پارامترهای زیر همسان شدند: سن، جنس، مصرف سیگار، پروفایل لیپیدی، بیماری‌های عروقی گذشته و سابقه‌ی جراحی چشم.
یافته‌ها: 95 بیمار  AMDمرد (55/8 درصد مرد با میانگین سنی 10/17 ± 69/93 سال) و 95 مورد گروه شاهد (31/6 درصد مرد، میانگین سنی 7/65 ± 65/50 سال) وارد مطالعه شدند. میانگین سطح سرب خون در گروه مورد و شاهد به ترتیب 70/08 ± 25/10 و 74/9 ± 24/25 میکروگرم در دسی‌لیتر بود (0/46 = P). همچنین پس از تعدیل عوامل مداخله‌گر، بین سطح سرب خون دو گروه تفاوت معنی‌داری مشاهده نشد (0/4 = P).
نتیجه‌گیری: بین بیماران مبتلا به AMD و گروه شاهد، تفاوت معنی‌داری در سطوح سرب خون که نشان‌دهنده‌ی مواجهه‌ی کوتاه‌مدت است، مشاهده نشد.

تازه های تحقیق

مصطفی فقهی: Google Scholar, PubMed

محمد ملک احمدی: Google Scholar, PubMed

فریدون فرهی:  PubMed

زهرا رمضانی: Google Scholar, PubMed

علی شهسواری: Google Scholar, PubMed

کلیدواژه‌ها
دژنراسیون ماکولا وابسته به سن
سرب
فلز
بیماری شبکیه

موضوعات

عنوان مقاله English

Blood Lead Levels in Patients with Age-Related Macular Degeneration: A Case-Control Study

نویسندگان English

Mina Puladvand 1
Mostafa Feghhi 2
Mohammad Malekahmadi 1
Ferydoun Farrahi 2
Zahra Ramezani 3
Ali Shahsavari 1
Pardis Tavallaeinejad 1
1 Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Ophthalmology, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Medicinal Chemistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده English

Background: This study aimed to evaluate blood lead levels in patients with age-related macular degeneration (AMD).
Methods: This case-control study was conducted on patients with AMD and healthy controls at Ahvaz, Khozestan, Iran. The control group was randomly selected from the general outpatient clinic. Two groups were matched for the following parameters: age, sex, smoking, lipid profiles, past vascular diseases, and history of ophthalmic surgery.
Findings: Ninety-five AMD patients (55.8% male, mean age 69.93 ± 10.17 years) and 95 controls (31.6% male, mean age 65.50 ± 7.65 years) were enrolled. The mean blood lead level in the case and control groups was
 25.70 ± 10.08 and 24.25 ± 9.74 µg/dL, respectively (P = 0.46). Also, after adjusting for confounding factors, there was no significant difference between the two groups' blood lead levels (P = 0.4).
Conclusion: No significant differences were found in the blood lead levels, indicative of short-term exposure, between patients with AMD and the control group.

کلیدواژه‌ها English

Age-related macular degeneration
Lead
Metal
Retinal disease
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مجله دانشکده پزشکی اصفهان
دوره 42، شماره 786
هفته 2، آذر
آذر و دی 1403
صفحه 876-883

  • تاریخ دریافت 06 شهریور 1403
  • تاریخ بازنگری 25 مهر 1403
  • تاریخ پذیرش 07 آبان 1403