تأثیر فعالیت ورزشی حاد و مزمن در شرایط هایپوکسی بر مقادیر گردش خونی فاکتور رشد اندوتلیال عروقی: مروری نظام‌مند و فراتحلیل

نوع مقاله : Review Article

نویسندگان

1 دانشیار، گروه علوم ورزشی، دانشکده‌ی علوم انسانی، دانشگاه کاشان، کاشان، ایران

2 استادیار، گروه علوم ورزشی، دانشکده‌ی علوم انسانی، دانشگاه کاشان، کاشان، ایران

10.48305/jims.v42.i789.0963

چکیده

مقاله مروری




مقدمه: هدف فراتحلیل حاضر، مقایسه‌ی تأثیر تمرین حاد و مزمن در شرایط هایپوکسی در برابر نورموکسی بر فاکتور رشد اندوتلیال عروقی (Vascular endothelial growth factor) VEGF می‌باشد.
روش‌ها: جستجوی جامع در پایگاه‌های اطلاعاتی PubMed، Web of Science و Scopus برای پیدا کردن مطالعات اصیل از زمان شروع تا تاریخ 30/01/1403انجام صورت گرفت. معیارهای ورود به تحقیق حاضر شامل مقالات منتشر ‌شده در مجلات فارسی و انگلیسی زبان، دارای آزمودنی‌های انسان، بررسی‌کننده‌ی اثر حاد و مزمن تمرین ورزشی در شرایط هایپوکسی در برابر تمرین ورزشی مشابه در شرایط نورموکسی و اندازه‌گیری مقادیر VEGF بودند. میانگین استاندارد شده (SMD) و فاصله‌ی اطمینان 95 درصد (CIs) با استفاده از مدل تصادفی محاسبه شد.
یافته‌ها: در مجموع، 16 مطالعه با 283 آزمودنی و دامنه‌ی سنی تقریبی بین 15 تا 30 سال وارد فراتحلیل شدند. نتایج تحلیل داده‌ها نشان داد که فعالیت ورزشی حاد در شرایط هایپوکسی [0/06 = P، 0/28 = SMD] و نورموکسی [0/13 = P، 0/25 = SMD] منجر به تغییرات معنی‌دار در VEGF بلافاصله بعد از فعالیت ورزشی نسبت به پیش از فعالیت ورزشی نمی‌شوند. با این حال، فعالیت ورزشی مزمن در شرایط هایپوکسی منجر به افزایش معنی‌دار VEGF نسبت به فعالیت ورزشی مزمن در شرایط نورموکسی می‌شود [0/001 = P، 0/76 = SMD].
نتیجه‌گیری: نتایج مطالعه‌ی حاضر نشان داد که فعالیت ورزشی حاد در شرایط هایپوکسی و نورموکسی اثرات قابل توجهی بر VEGF نداشت. فعالیت ورزشی مزمن در شرایط هایپوکسی ممکن است منجر به افزایش مقادیر گردش خونی VEGF نسبت به فعالیت ورزشی مزمن در شرایط نورموکسی شود که نشان‌دهنده‌ی نقش هایپوکسی در اثرات مفید تمرینات ورزشی می‌باشد.

تازه های تحقیق

محمد جواد پوروقار: Google Scholar 

موسی خلفی: Google Scholar 

 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of Acute and Chronic Exercise in Hypoxia on Circulating Vascular Endothelial Growth Factor Levels: A Systematic Review and Meta-Analysis

نویسندگان [English]

  • Mohammad Javad Pourvaghar 1
  • Mousa Khalafi 2
1 Associated Professor, Department of Sport Sciences, School of Humanities, University of Kashan, Kashan, Iran
2 Assistant Professor, Department of Sport Sciences, School of Humanities, University of Kashan, Kashan, Iran
چکیده [English]

Background: The present meta-analysis aims to compare the effect of acute and chronic exercise in hypoxia versus normoxia on vascular endothelial growth factor (VEGF).
Methods: In April 2024, a comprehensive search was conducted in PubMed, Web of Science, and Scopus databases to find original studies. The inclusion criteria for this study included articles published in Persian and English-language journals, with human subjects, investigating the acute and chronic effect of exercise training in hypoxia against similar exercise training in normoxia and measuring serum or plasma levels of vascular endothelial growth factor. Standardized mean (SMD) and 95% confidence intervals (CIs) were calculated using the random model.
Findings: A total of 16 studies with 283 subjects and an age range between 15 and 30 years were included in the meta-analysis. The results of data analysis showed that acute exercise in hypoxia [SMD: 0.28, P = 0.06] and normoxia [SMD: 0.25, P = 0.13] did not lead to significant changes in VEGF immediately after exercise when compared to pre-exercise. However, exercise training in hypoxia condition leads to a significant increase in VEGF compared to exercise training in normoxia [SMD: 0.76, P = 0.001].
Conclusion: The results showed that acute exercise training in hypoxia and normoxia had no significant effects on VEGF. Chronic exercise training in hypoxia may lead to an increase in circulating VEGF values compared to exercise training in normoxia, which indicates the role of hypoxia in the beneficial effects of exercise training.

کلیدواژه‌ها [English]

  • Hypoxia
  • Exercise
  • VEGF

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مجله دانشکده پزشکی اصفهان
دوره 42، شماره 789
هفته 1، دی
آذر و دی 1403
صفحه 963-973

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سابقه مقاله

  • تاریخ دریافت: 21 خرداد 1403
  • تاریخ پذیرش: 24 مهر 1403

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